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Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances
Melanoma develops from malignant transformations of the pigment-producing melanocytes. If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous, which is more frequent. However, as melanocytes are be found in the eyes, ears, gastrointestinal tract, genitalia, urinary...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232613/ https://www.ncbi.nlm.nih.gov/pubmed/34203771 http://dx.doi.org/10.3390/ijms22126395 |
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author | Strashilov, Strahil Yordanov, Angel |
author_facet | Strashilov, Strahil Yordanov, Angel |
author_sort | Strashilov, Strahil |
collection | PubMed |
description | Melanoma develops from malignant transformations of the pigment-producing melanocytes. If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous, which is more frequent. However, as melanocytes are be found in the eyes, ears, gastrointestinal tract, genitalia, urinary system, and meninges, cases of mucosal melanoma or other types (e.g., ocular) may occur. The incidence and morbidity of cutaneous melanoma (cM) are constantly increasing worldwide. Australia and New Zealand are world leaders in this regard with a morbidity rate of 54/100,000 and a mortality rate of 5.6/100,000 for 2015. The aim of this review is to consolidate and present the data related to the aetiology and pathogenesis of cutaneous melanoma, thus rendering them easier to understand. In this article we will discuss these problems and the possible impacts on treatment for this disease. |
format | Online Article Text |
id | pubmed-8232613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82326132021-06-26 Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances Strashilov, Strahil Yordanov, Angel Int J Mol Sci Review Melanoma develops from malignant transformations of the pigment-producing melanocytes. If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous, which is more frequent. However, as melanocytes are be found in the eyes, ears, gastrointestinal tract, genitalia, urinary system, and meninges, cases of mucosal melanoma or other types (e.g., ocular) may occur. The incidence and morbidity of cutaneous melanoma (cM) are constantly increasing worldwide. Australia and New Zealand are world leaders in this regard with a morbidity rate of 54/100,000 and a mortality rate of 5.6/100,000 for 2015. The aim of this review is to consolidate and present the data related to the aetiology and pathogenesis of cutaneous melanoma, thus rendering them easier to understand. In this article we will discuss these problems and the possible impacts on treatment for this disease. MDPI 2021-06-15 /pmc/articles/PMC8232613/ /pubmed/34203771 http://dx.doi.org/10.3390/ijms22126395 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Strashilov, Strahil Yordanov, Angel Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title | Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title_full | Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title_fullStr | Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title_full_unstemmed | Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title_short | Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances |
title_sort | aetiology and pathogenesis of cutaneous melanoma: current concepts and advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232613/ https://www.ncbi.nlm.nih.gov/pubmed/34203771 http://dx.doi.org/10.3390/ijms22126395 |
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