Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising. Recently, we discovered that the chemotherapeutic drug tamo...

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Detalles Bibliográficos
Autores principales: Selyunin, Andrey S., Nieves-Merced, Karinel, Li, Danyang, McHardy, Stanton F., Mukhopadhyay, Somshuvra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232625/
https://www.ncbi.nlm.nih.gov/pubmed/34203879
http://dx.doi.org/10.3390/toxins13060424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232625/
https://www.ncbi.nlm.nih.gov/pubmed/34203879
http://dx.doi.org/10.3390/toxins13060424

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