Cargando…

Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders

Mitochondrial disorders (MD) comprise a group of heterogeneous clinical disorders for which non-invasive diagnosis remains a challenge. Two protein biomarkers have so far emerged for MD detection, FGF-21 and GDF-15, but the identification of additional biomarkers capable of improving their diagnosti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peñas, Ana, Fernández-De la Torre, Miguel, Laine-Menéndez, Sara, Lora, David, Illescas, María, García-Bartolomé, Alberto, Morales-Conejo, Montserrat, Arenas, Joaquín, Martín, Miguel A., Morán, María, Domínguez-González, Cristina, Ugalde, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232645/ https://www.ncbi.nlm.nih.gov/pubmed/34203775 http://dx.doi.org/10.3390/ijms22126396

Ejemplares similares

Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction
por: García-Bartolomé, Alberto, et al.
Publicado: (2020)

Regulation of Mitochondrial Function by the Actin Cytoskeleton
por: Illescas, María, et al.
Publicado: (2021)

Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium
por: Vargas, Teo, et al.
Publicado: (2010)

The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response
por: Jena, Jayashree, et al.
Publicado: (2023)

Serum GDF-15 Levels Accurately Differentiate Patients with Primary Mitochondrial Myopathy, Manifesting with Exercise Intolerance and Fatigue, from Patients with Chronic Fatigue Syndrome
por: Bermejo-Guerrero, Laura, et al.
Publicado: (2023)

Pathophysiology of Cerebellar Degeneration in Mitochondrial Disorders: Insights from the Harlequin Mouse
por: Fernández de la Torre, Miguel, et al.
Publicado: (2023)

Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome
por: Guerrero-Molina, María Paz, et al.
Publicado: (2022)

Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects
por: Laine-Menéndez, Sara, et al.
Publicado: (2022)

Exercise Training and Neurodegeneration in Mitochondrial Disorders: Insights From the Harlequin Mouse
por: Fernández-de la Torre, Miguel, et al.
Publicado: (2020)

The Mitochondrial Biomarkers FGF-21 and GDF-15 in Patients with Episodic and Chronic Migraine
por: Burow, Philipp, et al.
Publicado: (2021)

Physical Exercise and Mitochondrial Disease: Insights From a Mouse Model
por: Fiuza-Luces, Carmen, et al.
Publicado: (2019)

Impact of the Mitochondrial Genetic Background in Complex III Deficiency
por: Gil Borlado, Mari Carmen, et al.
Publicado: (2010)

Accuracy of FGF‐21 and GDF‐15 for the diagnosis of mitochondrial disorders: A meta‐analysis
por: Lin, Yan, et al.
Publicado: (2020)

FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability
por: He, Jiahui, et al.
Publicado: (2023)

Kinetic analysis of F-actin depolymerization in the presence of platelet gelsolin and gelsolin-actin complexes
Publicado: (1985)

Preferent Diaphragmatic Involvement in TK2 Deficiency: An Autopsy Case Study
por: Laine-Menéndez, Sara, et al.
Publicado: (2021)

Localization and mobility of gelsolin in cells
Publicado: (1988)

Microinjection of gelsolin into living cells
Publicado: (1987)

Atypical Presentation of Gelsolin Amyloidosis in a Man of African Descent with a Novel Mutation in the Gelsolin Gene
por: Oregel, Karlos Z., et al.
Publicado: (2018)

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
por: Kang, Seul Gi, et al.
Publicado: (2021)

Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners
por: Campderrós, Laura, et al.
Publicado: (2020)

Chloride Induced Reinforcement Corrosion in Mortars Containing Coal Bottom Ash and Coal Fly Ash
por: Menéndez, Esperanza, et al.
Publicado: (2019)

Identification of secreted and cytosolic gelsolin in Drosophila
Publicado: (1994)

Plasma gelsolin as a biomarker of inflammation
por: DiNubile, Mark J
Publicado: (2008)

Plasma gelsolin promotes re-epithelialization
por: Wittmann, J., et al.
Publicado: (2018)

Gelsolin-Like Domain 3 Plays Vital Roles in Regulating the Activities of the Lily Villin/Gelsolin/Fragmin Superfamily
por: Qian, Dong, et al.
Publicado: (2015)

Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin
por: Khatri, Neeraj, et al.
Publicado: (2014)

The protective effects of plasma gelsolin on stroke outcome in rats
por: Le, Huong T, et al.
Publicado: (2011)

Novel NDUFA13 Mutations Associated with OXPHOS Deficiency and Leigh Syndrome: A Second Family Report
por: González-Quintana, Adrián, et al.
Publicado: (2020)

Circulating FGF21 and GDF15 as Biomarkers for Screening, Diagnosis, and Severity Assessment of Primary Mitochondrial Disorders in Children
por: Li, Yi, et al.
Publicado: (2022)

Cord Blood FGF-21 and GDF-15 Levels Are Affected by Maternal Exposure to Moderate to Severe Anemia and Malaria
por: Hjort, Line, et al.
Publicado: (2023)

Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis
por: Osborn, Teresia M, et al.
Publicado: (2008)

Identification of critical functional and regulatory domains in gelsolin
Publicado: (1989)

A re-evaluation of cytoplasmic gelsolin localization
Publicado: (1986)

The actin filament-severing domain of plasma gelsolin
Publicado: (1986)

Gelsolin has three actin-binding sites
Publicado: (1988)

Delayed Retraction of Filopodia in Gelsolin Null Mice
por: Lu, Mei, et al.
Publicado: (1997)

Mutation in gelsolin gene in Finnish hereditary amyloidosis
Publicado: (1990)

Gelsolin-Independent Podosome Formation in Dendritic Cells
por: Hammarfjord, Oscar, et al.
Publicado: (2011)

ATP competes with PIP(2) for binding to gelsolin
por: Szatmári, Dávid, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ltlndnrgucn9000m27ih7s3c2d