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Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today

Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and p...

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Autores principales: Bazzan, Erica, Tinè, Mariaenrica, Casara, Alvise, Biondini, Davide, Semenzato, Umberto, Cocconcelli, Elisabetta, Balestro, Elisabetta, Damin, Marco, Radu, Claudia Maria, Turato, Graziella, Baraldo, Simonetta, Simioni, Paolo, Spagnolo, Paolo, Saetta, Marina, Cosio, Manuel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232679/
https://www.ncbi.nlm.nih.gov/pubmed/34203956
http://dx.doi.org/10.3390/ijms22126417
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author Bazzan, Erica
Tinè, Mariaenrica
Casara, Alvise
Biondini, Davide
Semenzato, Umberto
Cocconcelli, Elisabetta
Balestro, Elisabetta
Damin, Marco
Radu, Claudia Maria
Turato, Graziella
Baraldo, Simonetta
Simioni, Paolo
Spagnolo, Paolo
Saetta, Marina
Cosio, Manuel G.
author_facet Bazzan, Erica
Tinè, Mariaenrica
Casara, Alvise
Biondini, Davide
Semenzato, Umberto
Cocconcelli, Elisabetta
Balestro, Elisabetta
Damin, Marco
Radu, Claudia Maria
Turato, Graziella
Baraldo, Simonetta
Simioni, Paolo
Spagnolo, Paolo
Saetta, Marina
Cosio, Manuel G.
author_sort Bazzan, Erica
collection PubMed
description Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a “more questions than answers” chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed.
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spelling pubmed-82326792021-06-26 Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today Bazzan, Erica Tinè, Mariaenrica Casara, Alvise Biondini, Davide Semenzato, Umberto Cocconcelli, Elisabetta Balestro, Elisabetta Damin, Marco Radu, Claudia Maria Turato, Graziella Baraldo, Simonetta Simioni, Paolo Spagnolo, Paolo Saetta, Marina Cosio, Manuel G. Int J Mol Sci Review Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a “more questions than answers” chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed. MDPI 2021-06-15 /pmc/articles/PMC8232679/ /pubmed/34203956 http://dx.doi.org/10.3390/ijms22126417 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bazzan, Erica
Tinè, Mariaenrica
Casara, Alvise
Biondini, Davide
Semenzato, Umberto
Cocconcelli, Elisabetta
Balestro, Elisabetta
Damin, Marco
Radu, Claudia Maria
Turato, Graziella
Baraldo, Simonetta
Simioni, Paolo
Spagnolo, Paolo
Saetta, Marina
Cosio, Manuel G.
Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title_full Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title_fullStr Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title_full_unstemmed Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title_short Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
title_sort critical review of the evolution of extracellular vesicles’ knowledge: from 1946 to today
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232679/
https://www.ncbi.nlm.nih.gov/pubmed/34203956
http://dx.doi.org/10.3390/ijms22126417
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