Effects of a Novel Thiadiazole Derivative with High Anticancer Activity on Cancer Cell Immunogenic Markers: Mismatch Repair System, PD-L1 Expression, and Tumor Mutation Burden

Microsatellite instability (MSI), tumor mutation burden (TMB), and programmed cell death ligand-1 (PD-L1) are particularly known as immunotherapy predictive biomarkers. MSI and TMB are closely related to DNA mismatch repair (MMR) pathway functionality, while the PD-L1 checkpoint mediates cancer cell...

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Detalles Bibliográficos
Autores principales: Sagredou, Sofia, Dalezis, Panagiotis, Papadopoulou, Eirini, Voura, Maria, Deligiorgi, Maria V., Nikolaou, Michail, Panayiotidis, Mihalis I., Nasioulas, George, Sarli, Vasiliki, Trafalis, Dimitrios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232699/
https://www.ncbi.nlm.nih.gov/pubmed/34203761
http://dx.doi.org/10.3390/pharmaceutics13060885

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