A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

SIMPLE SUMMARY: The telomeric protein TRF2 (Telomeric repeat-binding factor 2) is upregulated in human cancers and associated with poor prognosis. TRF2 oncogenic properties rely on its intrinsic telomere protective role, but also on cell extrinsic effects through immunosuppressive and angiogenic act...

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Autores principales: El Maï, Mounir, Janho dit Hreich, Serena, Gaggioli, Cedric, Roisin, Armelle, Wagner, Nicole, Ye, Jing, Jalinot, Pierre, Cherfils-Vicini, Julien, Gilson, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232760/
https://www.ncbi.nlm.nih.gov/pubmed/34203903
http://dx.doi.org/10.3390/cancers13122998

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