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Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population

Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, SLC6A2 (rs1805065) and SYNE1 (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and...

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Autores principales: Fichna, Jakub P., Humińska-Lisowska, Kinga, Safranow, Krzysztof, Adamczyk, Jakub G., Cięszczyk, Paweł, Żekanowski, Cezary, Berdyński, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232774/
https://www.ncbi.nlm.nih.gov/pubmed/34203885
http://dx.doi.org/10.3390/genes12060919
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author Fichna, Jakub P.
Humińska-Lisowska, Kinga
Safranow, Krzysztof
Adamczyk, Jakub G.
Cięszczyk, Paweł
Żekanowski, Cezary
Berdyński, Mariusz
author_facet Fichna, Jakub P.
Humińska-Lisowska, Kinga
Safranow, Krzysztof
Adamczyk, Jakub G.
Cięszczyk, Paweł
Żekanowski, Cezary
Berdyński, Mariusz
author_sort Fichna, Jakub P.
collection PubMed
description Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, SLC6A2 (rs1805065) and SYNE1 (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and 305 combat athletes) vs. 1009 sedentary controls. Genotyping of selected SNPs was performed using TaqMan SNP genotyping assays. SLC6A2 codes for norepinephrine transporter, a protein involved in modulating mood, arousal, memory, learning, and pain perception, while SYNE1 encodes protein important for the maintenance of the cerebellum—the part of the brain that coordinates complex body movements. Both SNPs (rs2635438 and rs1805065) showed no statistically significant differences between the frequencies of variants in the athletes and the sedentary controls (athletes vs. control group) or in the athlete subgroups (martial vs. control, endurance vs. control, and power vs. control). The rs1805065 T variant of SLC6A2 was found to be overrepresented in male high-elite martial sports athletes when compared to sedentary controls (OR = 6.56, 95%CI = 1.82–23.59, p = 0.010). This supports the hypothesis that genetic variants potentially affecting brain functioning can influence elite athletic performance and indicate the need for further genetic association studies, as well as functional analyses.
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spelling pubmed-82327742021-06-26 Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population Fichna, Jakub P. Humińska-Lisowska, Kinga Safranow, Krzysztof Adamczyk, Jakub G. Cięszczyk, Paweł Żekanowski, Cezary Berdyński, Mariusz Genes (Basel) Article Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, SLC6A2 (rs1805065) and SYNE1 (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and 305 combat athletes) vs. 1009 sedentary controls. Genotyping of selected SNPs was performed using TaqMan SNP genotyping assays. SLC6A2 codes for norepinephrine transporter, a protein involved in modulating mood, arousal, memory, learning, and pain perception, while SYNE1 encodes protein important for the maintenance of the cerebellum—the part of the brain that coordinates complex body movements. Both SNPs (rs2635438 and rs1805065) showed no statistically significant differences between the frequencies of variants in the athletes and the sedentary controls (athletes vs. control group) or in the athlete subgroups (martial vs. control, endurance vs. control, and power vs. control). The rs1805065 T variant of SLC6A2 was found to be overrepresented in male high-elite martial sports athletes when compared to sedentary controls (OR = 6.56, 95%CI = 1.82–23.59, p = 0.010). This supports the hypothesis that genetic variants potentially affecting brain functioning can influence elite athletic performance and indicate the need for further genetic association studies, as well as functional analyses. MDPI 2021-06-15 /pmc/articles/PMC8232774/ /pubmed/34203885 http://dx.doi.org/10.3390/genes12060919 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fichna, Jakub P.
Humińska-Lisowska, Kinga
Safranow, Krzysztof
Adamczyk, Jakub G.
Cięszczyk, Paweł
Żekanowski, Cezary
Berdyński, Mariusz
Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title_full Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title_fullStr Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title_full_unstemmed Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title_short Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population
title_sort rare variant in the slc6a2 encoding a norepinephrine transporter is associated with elite athletic performance in the polish population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232774/
https://www.ncbi.nlm.nih.gov/pubmed/34203885
http://dx.doi.org/10.3390/genes12060919
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