Impact of Preprocessing and Harmonization Methods on the Removal of Scanner Effects in Brain MRI Radiomic Features

SIMPLE SUMMARY: As a rapid-development research field, radiomics-based analysis has been applied to many clinical problems. However, the reproducibility of the radiomics studies remain challenging especially when data suffers from scanner effects, a kind of non-biological variations introduced by different image acquiring settings. This study aims to investigate how the image preprocessing methods (N4 bias field correction and image resampling) and the harmonization methods (intensity normalization methods working on images and ComBat method working on radiomic features) help to remove the scanner effects and improve the radiomics reproducibility in brain MRI radiomics. ABSTRACT: In brain MRI radiomics studies, the non-biological variations introduced by different image acquisition settings, namely scanner effects, affect the reliability and reproducibility of the radiomics results. This paper assesses how the preprocessing methods (including N4 bias field correction and image resampling) and the harmonization methods (either the six intensity normalization methods working on brain MRI images or the ComBat method working on radiomic features) help to remove the scanner effects and improve the radiomic feature reproducibility in brain MRI radiomics. The analyses were based on in vitro datasets (homogeneous and heterogeneous phantom data) and in vivo datasets (brain MRI images collected from healthy volunteers and clinical patients with brain tumors). The results show that the ComBat method is essential and vital to remove scanner effects in brain MRI radiomic studies. Moreover, the intensity normalization methods, while not able to remove scanner effects at the radiomic feature level, still yield more comparable MRI images and improve the robustness of the harmonized features to the choice among ComBat implementations.