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Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans
Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232903/ https://www.ncbi.nlm.nih.gov/pubmed/34172445 http://dx.doi.org/10.1126/sciadv.abg3012 |
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author | Calculli, Giuseppe Lee, Hyun Ju Shen, Koning Pham, Uyen Herholz, Marija Trifunovic, Aleksandra Dillin, Andrew Vilchez, David |
author_facet | Calculli, Giuseppe Lee, Hyun Ju Shen, Koning Pham, Uyen Herholz, Marija Trifunovic, Aleksandra Dillin, Andrew Vilchez, David |
author_sort | Calculli, Giuseppe |
collection | PubMed |
description | Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis of the germ line influences somatic tissues. To this end, we induce aggregation of germline-specific PGL-1 protein in germline stem cells of Caenorhabditis elegans. Besides altering the intracellular mitochondrial network of germline cells, PGL-1 aggregation also reduces the mitochondrial content of somatic tissues through long-range Wnt signaling pathway. This process induces the unfolded protein response of the mitochondria in the soma, promoting somatic mitochondrial fragmentation and aggregation of proteins linked with neurodegenerative diseases such as Huntington’s and amyotrophic lateral sclerosis. Thus, the proteostasis status of germline stem cells coordinates mitochondrial networks and protein aggregation through the organism. |
format | Online Article Text |
id | pubmed-8232903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82329032021-07-06 Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans Calculli, Giuseppe Lee, Hyun Ju Shen, Koning Pham, Uyen Herholz, Marija Trifunovic, Aleksandra Dillin, Andrew Vilchez, David Sci Adv Research Articles Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis of the germ line influences somatic tissues. To this end, we induce aggregation of germline-specific PGL-1 protein in germline stem cells of Caenorhabditis elegans. Besides altering the intracellular mitochondrial network of germline cells, PGL-1 aggregation also reduces the mitochondrial content of somatic tissues through long-range Wnt signaling pathway. This process induces the unfolded protein response of the mitochondria in the soma, promoting somatic mitochondrial fragmentation and aggregation of proteins linked with neurodegenerative diseases such as Huntington’s and amyotrophic lateral sclerosis. Thus, the proteostasis status of germline stem cells coordinates mitochondrial networks and protein aggregation through the organism. American Association for the Advancement of Science 2021-06-25 /pmc/articles/PMC8232903/ /pubmed/34172445 http://dx.doi.org/10.1126/sciadv.abg3012 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Calculli, Giuseppe Lee, Hyun Ju Shen, Koning Pham, Uyen Herholz, Marija Trifunovic, Aleksandra Dillin, Andrew Vilchez, David Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title | Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title_full | Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title_fullStr | Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title_full_unstemmed | Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title_short | Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans |
title_sort | systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of c. elegans |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232903/ https://www.ncbi.nlm.nih.gov/pubmed/34172445 http://dx.doi.org/10.1126/sciadv.abg3012 |
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