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Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans
Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis o...
Autores principales: | Calculli, Giuseppe, Lee, Hyun Ju, Shen, Koning, Pham, Uyen, Herholz, Marija, Trifunovic, Aleksandra, Dillin, Andrew, Vilchez, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232903/ https://www.ncbi.nlm.nih.gov/pubmed/34172445 http://dx.doi.org/10.1126/sciadv.abg3012 |
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