Cargando…

New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants

Gut microbiota and the central nervous system have parallel developmental windows during pre and post-natal life. Increasing evidences suggest that intestinal dysbiosis in preterm infants predisposes the neonate to adverse neurological outcomes later in life. Understanding the link between gut micro...

Descripción completa

Detalles Bibliográficos
Autores principales: Buffet-Bataillon, Sylvie, Bellanger, Amandine, Boudry, Gaelle, Gangneux, Jean-Pierre, Yverneau, Mathilde, Beuchée, Alain, Blat, Sophie, Le Huërou-Luron, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232935/
https://www.ncbi.nlm.nih.gov/pubmed/34177860
http://dx.doi.org/10.3389/fmicb.2021.676622
_version_ 1783713742198931456
author Buffet-Bataillon, Sylvie
Bellanger, Amandine
Boudry, Gaelle
Gangneux, Jean-Pierre
Yverneau, Mathilde
Beuchée, Alain
Blat, Sophie
Le Huërou-Luron, Isabelle
author_facet Buffet-Bataillon, Sylvie
Bellanger, Amandine
Boudry, Gaelle
Gangneux, Jean-Pierre
Yverneau, Mathilde
Beuchée, Alain
Blat, Sophie
Le Huërou-Luron, Isabelle
author_sort Buffet-Bataillon, Sylvie
collection PubMed
description Gut microbiota and the central nervous system have parallel developmental windows during pre and post-natal life. Increasing evidences suggest that intestinal dysbiosis in preterm infants predisposes the neonate to adverse neurological outcomes later in life. Understanding the link between gut microbiota colonization and brain development to tailor therapies aimed at optimizing initial colonization and microbiota development are promising strategies to warrant adequate brain development and enhance neurological outcomes in preterm infants. Breast-feeding has been associated with both adequate cognitive development and healthy microbiota in preterms. Infant formula are industrially produced substitutes for infant nutrition that do not completely recapitulate breast-feeding benefices and could be largely improved by the understanding of the role of breast milk components upon gut microbiota. In this review, we will first discuss the nutritional and bioactive component information on breast milk composition and its contribution to the assembly of the neonatal gut microbiota in preterms. We will then discuss the emerging pathways connecting the gut microbiota and brain development. Finally, we will discuss the promising microbiota modulation-based nutritional interventions (including probiotic and prebiotic supplementation of infant formula and maternal nutrition) for improving neurodevelopmental outcomes.
format Online
Article
Text
id pubmed-8232935
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82329352021-06-26 New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants Buffet-Bataillon, Sylvie Bellanger, Amandine Boudry, Gaelle Gangneux, Jean-Pierre Yverneau, Mathilde Beuchée, Alain Blat, Sophie Le Huërou-Luron, Isabelle Front Microbiol Microbiology Gut microbiota and the central nervous system have parallel developmental windows during pre and post-natal life. Increasing evidences suggest that intestinal dysbiosis in preterm infants predisposes the neonate to adverse neurological outcomes later in life. Understanding the link between gut microbiota colonization and brain development to tailor therapies aimed at optimizing initial colonization and microbiota development are promising strategies to warrant adequate brain development and enhance neurological outcomes in preterm infants. Breast-feeding has been associated with both adequate cognitive development and healthy microbiota in preterms. Infant formula are industrially produced substitutes for infant nutrition that do not completely recapitulate breast-feeding benefices and could be largely improved by the understanding of the role of breast milk components upon gut microbiota. In this review, we will first discuss the nutritional and bioactive component information on breast milk composition and its contribution to the assembly of the neonatal gut microbiota in preterms. We will then discuss the emerging pathways connecting the gut microbiota and brain development. Finally, we will discuss the promising microbiota modulation-based nutritional interventions (including probiotic and prebiotic supplementation of infant formula and maternal nutrition) for improving neurodevelopmental outcomes. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8232935/ /pubmed/34177860 http://dx.doi.org/10.3389/fmicb.2021.676622 Text en Copyright © 2021 Buffet-Bataillon, Bellanger, Boudry, Gangneux, Yverneau, Beuchée, Blat and Le Huërou-Luron. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Buffet-Bataillon, Sylvie
Bellanger, Amandine
Boudry, Gaelle
Gangneux, Jean-Pierre
Yverneau, Mathilde
Beuchée, Alain
Blat, Sophie
Le Huërou-Luron, Isabelle
New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title_full New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title_fullStr New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title_full_unstemmed New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title_short New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants
title_sort new insights into microbiota modulation-based nutritional interventions for neurodevelopmental outcomes in preterm infants
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232935/
https://www.ncbi.nlm.nih.gov/pubmed/34177860
http://dx.doi.org/10.3389/fmicb.2021.676622
work_keys_str_mv AT buffetbataillonsylvie newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT bellangeramandine newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT boudrygaelle newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT gangneuxjeanpierre newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT yverneaumathilde newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT beucheealain newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT blatsophie newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants
AT lehuerouluronisabelle newinsightsintomicrobiotamodulationbasednutritionalinterventionsforneurodevelopmentaloutcomesinpreterminfants