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Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) exposure may cause various diseases. However, the association between PAHs exposure and kidney stones remains unclear. The purpose of this study was to examine the relationship between PAHs and the risk of kidney stones in the US population. METHOD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232959/ https://www.ncbi.nlm.nih.gov/pubmed/34188522 http://dx.doi.org/10.2147/IJGM.S319779 |
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author | Sun, Si Mao, Weipu Tao, Shuchun Zou, Xiangyu Tian, Shengwei Qian, Siwei Yao, Chi Zhang, Guangyuan Chen, Ming |
author_facet | Sun, Si Mao, Weipu Tao, Shuchun Zou, Xiangyu Tian, Shengwei Qian, Siwei Yao, Chi Zhang, Guangyuan Chen, Ming |
author_sort | Sun, Si |
collection | PubMed |
description | BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) exposure may cause various diseases. However, the association between PAHs exposure and kidney stones remains unclear. The purpose of this study was to examine the relationship between PAHs and the risk of kidney stones in the US population. METHODS: The study included a total of 30,442 individuals (≥20 years) from the 2007–2012 National Health and Nutrition Examination Survey (NHANES). Nine urinary PAHs were included in this study. Logistic regression and dose–response curves were used to evaluate the association between PAHs and the risk of kidney stones. RESULTS: We selected 4385 participants. The dose–response curves showed a significant positive association between total PAHs, 2-hydroxynaphthalene, 1-hydroxyphenanthrene, 2-hydroxyphenanthrene, 9-hydroxyfluorene and the risk of kidney stones after adjusting for confounding factors. Compared with the low group, an increased risk of kidney stones was observed in the high group of total PAHs [OR (95% CI), 1.32 (1.06–1.64), P=0.013], 2-hydroxynaphthalene [OR (95% CI), 1.37 (1.10–1.71), P=0.005], 1-hydroxyphenanthrene [OR (95% CI), 1.24 (1.00–1.54), P=0.046] and 9-hydroxyfluorene [OR (95% CI), 1.36 (1.09–1.70), P=0.007]. CONCLUSION: High levels of PAHs were positively associated with the risk of kidney stones in the US population. |
format | Online Article Text |
id | pubmed-8232959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-82329592021-06-28 Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 Sun, Si Mao, Weipu Tao, Shuchun Zou, Xiangyu Tian, Shengwei Qian, Siwei Yao, Chi Zhang, Guangyuan Chen, Ming Int J Gen Med Original Research BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) exposure may cause various diseases. However, the association between PAHs exposure and kidney stones remains unclear. The purpose of this study was to examine the relationship between PAHs and the risk of kidney stones in the US population. METHODS: The study included a total of 30,442 individuals (≥20 years) from the 2007–2012 National Health and Nutrition Examination Survey (NHANES). Nine urinary PAHs were included in this study. Logistic regression and dose–response curves were used to evaluate the association between PAHs and the risk of kidney stones. RESULTS: We selected 4385 participants. The dose–response curves showed a significant positive association between total PAHs, 2-hydroxynaphthalene, 1-hydroxyphenanthrene, 2-hydroxyphenanthrene, 9-hydroxyfluorene and the risk of kidney stones after adjusting for confounding factors. Compared with the low group, an increased risk of kidney stones was observed in the high group of total PAHs [OR (95% CI), 1.32 (1.06–1.64), P=0.013], 2-hydroxynaphthalene [OR (95% CI), 1.37 (1.10–1.71), P=0.005], 1-hydroxyphenanthrene [OR (95% CI), 1.24 (1.00–1.54), P=0.046] and 9-hydroxyfluorene [OR (95% CI), 1.36 (1.09–1.70), P=0.007]. CONCLUSION: High levels of PAHs were positively associated with the risk of kidney stones in the US population. Dove 2021-06-21 /pmc/articles/PMC8232959/ /pubmed/34188522 http://dx.doi.org/10.2147/IJGM.S319779 Text en © 2021 Sun et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Sun, Si Mao, Weipu Tao, Shuchun Zou, Xiangyu Tian, Shengwei Qian, Siwei Yao, Chi Zhang, Guangyuan Chen, Ming Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title | Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title_full | Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title_fullStr | Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title_full_unstemmed | Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title_short | Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007–2012 |
title_sort | polycyclic aromatic hydrocarbons and the risk of kidney stones in us adults: an exposure-response analysis of nhanes 2007–2012 |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232959/ https://www.ncbi.nlm.nih.gov/pubmed/34188522 http://dx.doi.org/10.2147/IJGM.S319779 |
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