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Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection

Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near...

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Autores principales: Dietz-Pfeilstetter, Antje, Mendelsohn, Mike, Gathmann, Achim, Klinkenbuß, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232971/
https://www.ncbi.nlm.nih.gov/pubmed/34177998
http://dx.doi.org/10.3389/fpls.2021.682387
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author Dietz-Pfeilstetter, Antje
Mendelsohn, Mike
Gathmann, Achim
Klinkenbuß, Dominik
author_facet Dietz-Pfeilstetter, Antje
Mendelsohn, Mike
Gathmann, Achim
Klinkenbuß, Dominik
author_sort Dietz-Pfeilstetter, Antje
collection PubMed
description Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near future, is based on the natural gene silencing mechanism RNA interference (RNAi). These dsRNA-based products can be highly specific for a target organism due to the sequence-specific interaction between effective small interfering RNAs (siRNAs) and a complementary target RNA. General regulatory frameworks for pesticide authorization in the U.S. and in the EU are presented. In addition, production and application procedures and specific characteristics of dsRNA-based pesticides relevant for risk assessment and regulation are considered.
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spelling pubmed-82329712021-06-26 Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection Dietz-Pfeilstetter, Antje Mendelsohn, Mike Gathmann, Achim Klinkenbuß, Dominik Front Plant Sci Plant Science Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near future, is based on the natural gene silencing mechanism RNA interference (RNAi). These dsRNA-based products can be highly specific for a target organism due to the sequence-specific interaction between effective small interfering RNAs (siRNAs) and a complementary target RNA. General regulatory frameworks for pesticide authorization in the U.S. and in the EU are presented. In addition, production and application procedures and specific characteristics of dsRNA-based pesticides relevant for risk assessment and regulation are considered. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8232971/ /pubmed/34177998 http://dx.doi.org/10.3389/fpls.2021.682387 Text en Copyright © 2021 Dietz-Pfeilstetter, Mendelsohn, Gathmann and Klinkenbuß. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Dietz-Pfeilstetter, Antje
Mendelsohn, Mike
Gathmann, Achim
Klinkenbuß, Dominik
Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title_full Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title_fullStr Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title_full_unstemmed Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title_short Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
title_sort considerations and regulatory approaches in the usa and in the eu for dsrna-based externally applied pesticides for plant protection
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232971/
https://www.ncbi.nlm.nih.gov/pubmed/34177998
http://dx.doi.org/10.3389/fpls.2021.682387
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