A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia

We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized rati...

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Detalles Bibliográficos
Autores principales: Kiparizoska, Sara, Davis, Willam, Duong, Michelle, Griffith, Nayrana, Hsu, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232982/
https://www.ncbi.nlm.nih.gov/pubmed/34188984
http://dx.doi.org/10.7759/cureus.15242
Descripción
Sumario:We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized ratio of 7.1. Liver biopsy showed significant confluent necrosis involving >70% of the liver tissue. He was listed for a liver transplant but was ultimately taken off of because of significant improvement with treatment by N-acetylcysteine infusion. Through our research, we found that symptoms of hepatitis can be seen with psychotic disorders, but ALF is rare.

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