A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia

We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized rati...

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Autores principales: Kiparizoska, Sara, Davis, Willam, Duong, Michelle, Griffith, Nayrana, Hsu, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232982/
https://www.ncbi.nlm.nih.gov/pubmed/34188984
http://dx.doi.org/10.7759/cureus.15242
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author Kiparizoska, Sara
Davis, Willam
Duong, Michelle
Griffith, Nayrana
Hsu, Christine
author_facet Kiparizoska, Sara
Davis, Willam
Duong, Michelle
Griffith, Nayrana
Hsu, Christine
author_sort Kiparizoska, Sara
collection PubMed
description We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized ratio of 7.1. Liver biopsy showed significant confluent necrosis involving >70% of the liver tissue. He was listed for a liver transplant but was ultimately taken off of because of significant improvement with treatment by N-acetylcysteine infusion. Through our research, we found that symptoms of hepatitis can be seen with psychotic disorders, but ALF is rare.
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spelling pubmed-82329822021-06-28 A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia Kiparizoska, Sara Davis, Willam Duong, Michelle Griffith, Nayrana Hsu, Christine Cureus Psychiatry We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized ratio of 7.1. Liver biopsy showed significant confluent necrosis involving >70% of the liver tissue. He was listed for a liver transplant but was ultimately taken off of because of significant improvement with treatment by N-acetylcysteine infusion. Through our research, we found that symptoms of hepatitis can be seen with psychotic disorders, but ALF is rare. Cureus 2021-05-25 /pmc/articles/PMC8232982/ /pubmed/34188984 http://dx.doi.org/10.7759/cureus.15242 Text en Copyright © 2021, Kiparizoska et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Psychiatry
Kiparizoska, Sara
Davis, Willam
Duong, Michelle
Griffith, Nayrana
Hsu, Christine
A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title_full A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title_fullStr A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title_full_unstemmed A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title_short A Gut Feeling: Acute Liver Failure – An Unusual Manifestation of Malignant Catatonia
title_sort gut feeling: acute liver failure – an unusual manifestation of malignant catatonia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232982/
https://www.ncbi.nlm.nih.gov/pubmed/34188984
http://dx.doi.org/10.7759/cureus.15242
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