Cargando…

Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development

Swertiamarin, a seco-iridoid glycoside, is mainly found in Enicostemma littorale Blume (E. littorale) and exhibits therapeutic activities for various diseases. The present study aimed to provide a review of swertiamarin in terms of its phytochemistry, physicochemical properties, biosynthesis, pharma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muhamad Fadzil, Nur Sakinah, Sekar, Mahendran, Gan, Siew Hua, Bonam, Srinivasa Reddy, Wu, Yuan Seng, Vaijanathappa, Jaishree, Ravi, Subban, Lum, Pei Teng, Dhadde, Shivsharan B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233004/ https://www.ncbi.nlm.nih.gov/pubmed/34188450 http://dx.doi.org/10.2147/DDDT.S299753

Ejemplares similares

Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review
por: Azman, Shazalyana, et al.
Publicado: (2021)

Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development
por: Watroly, Mohd Nasarudin, et al.
Publicado: (2021)

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
por: Mohd Zaid, Nurul Amirah, et al.
Publicado: (2022)

Embelin Alleviates Severe Airway Inflammation in OVA-LPS-Induced Rat Model of Allergic Asthma
por: Azman, Shazalyana, et al.
Publicado: (2021)

Protective effect of mangiferin on memory impairment: A systematic review
por: Lum, Pei Teng, et al.
Publicado: (2021)

Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action
por: Zuraini, Nur Zulaikha Azwa, et al.
Publicado: (2021)

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action
por: Yap, Kah Min, et al.
Publicado: (2021)

Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review
por: Lum, Pei Teng, et al.
Publicado: (2022)

Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy
por: Mustafa, Nur Hanisah, et al.
Publicado: (2022)

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
por: Fuloria, Shivkanya, et al.
Publicado: (2022)

Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment
por: Fuloria, Shivkanya, et al.
Publicado: (2022)

Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy
por: Nabihah Nasir, Naurah, et al.
Publicado: (2023)

PA03.06. Swertiamarin A novel lead to antidepressants
por: Dharaniyambigai, K, et al.
Publicado: (2013)

Acetylated and propionated derivatives of swertiamarin have anti-adipogenic effects
por: Vaidya, Hitesh B, et al.
Publicado: (2014)

Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice: Swertiamarin reverses obesity by enhancing energy expenditure
por: Zhu, Yuqin, et al.
Publicado: (2022)

Celastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment
por: Amir Yusri, Muhamad Azrul, et al.
Publicado: (2023)

Kirenol: A Potential Natural Lead Molecule for a New Drug Design, Development, and Therapy for Inflammation
por: Nasir, Naurah Nabihah, et al.
Publicado: (2022)

Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders
por: Khattulanuar, Farrah Syazana, et al.
Publicado: (2022)

Bioinformatics analysis of differentially expressed genes in hepatocellular carcinoma cells exposed to Swertiamarin
por: Tang, Haoran, et al.
Publicado: (2019)

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects
por: Yap, Kah Min, et al.
Publicado: (2021)

In silico docking studies for designing potent anti-diabetic derivatives of swertiamarin with enzyme HMG COA reductase
por: Bhatt, Jayshil, et al.
Publicado: (2014)

Swertiamarin suppresses proliferation, migration, and invasion of hepatocellular carcinoma cells via negative regulation of FRAT1
por: Xiao, Shufeng, et al.
Publicado: (2020)

Identification and validation of targets of swertiamarin on idiopathic pulmonary fibrosis through bioinformatics and molecular docking-based approach
por: Chang, Jun, et al.
Publicado: (2023)

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
por: Rahim, Nur Syafiqah, et al.
Publicado: (2023)

Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats
por: Zhang, Qianrui, et al.
Publicado: (2019)

The anti-inflammation, anti-oxidative and anti-fibrosis properties of swertiamarin in cigarette smoke exposure-induced prostate dysfunction in rats
por: Chen, Jinglou, et al.
Publicado: (2019)

Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet
por: Xu, Liang, et al.
Publicado: (2021)

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

Lysosomes as a therapeutic target
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2021)

Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients
por: Belani, Muskaan A., et al.
Publicado: (2023)

Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 Pandemic
por: Saksena, Nitin, et al.
Publicado: (2021)

Retrospective analysis on the immunopotentiating mechanism of an emulsion-based vaccine adjuvant on human antigen presenting cells
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2023)

Determination and Pharmacokinetic Study of Gentiopicroside, Geniposide, Baicalin, and Swertiamarin in Chinese Herbal Formulae after Oral Administration in Rats by LC-MS/MS
por: Lu, Chia-Ming, et al.
Publicado: (2014)

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways
por: Zhou, Qian, et al.
Publicado: (2023)

Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature
por: Yap, Kah Min, et al.
Publicado: (2021)

Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms
por: Lum, Pei Teng, et al.
Publicado: (2023)

PHYTOCHEMICAL, PHARMACOLOGICAL AND BIOLOGICAL PROFILES OF TRAGIA SPECIES (FAMILY: EUPHORBIACEAE)
por: Reddy, Bonam Srinivasa, et al.
Publicado: (2017)

Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2020)

IFN-γ Induces PD-L1 Expression in Primed Human Basophils
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_35i9a5brmiilq3fst636l6sm46