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Scaling of subcellular actin structures with cell length through decelerated growth
How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233038/ https://www.ncbi.nlm.nih.gov/pubmed/34114567 http://dx.doi.org/10.7554/eLife.68424 |
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author | McInally, Shane G Kondev, Jane Goode, Bruce L |
author_facet | McInally, Shane G Kondev, Jane Goode, Bruce L |
author_sort | McInally, Shane G |
collection | PubMed |
description | How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a ‘balance-point’ model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell. |
format | Online Article Text |
id | pubmed-8233038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82330382021-06-28 Scaling of subcellular actin structures with cell length through decelerated growth McInally, Shane G Kondev, Jane Goode, Bruce L eLife Cell Biology How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a ‘balance-point’ model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell. eLife Sciences Publications, Ltd 2021-06-11 /pmc/articles/PMC8233038/ /pubmed/34114567 http://dx.doi.org/10.7554/eLife.68424 Text en © 2021, McInally et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Cell Biology McInally, Shane G Kondev, Jane Goode, Bruce L Scaling of subcellular actin structures with cell length through decelerated growth |
title | Scaling of subcellular actin structures with cell length through decelerated growth |
title_full | Scaling of subcellular actin structures with cell length through decelerated growth |
title_fullStr | Scaling of subcellular actin structures with cell length through decelerated growth |
title_full_unstemmed | Scaling of subcellular actin structures with cell length through decelerated growth |
title_short | Scaling of subcellular actin structures with cell length through decelerated growth |
title_sort | scaling of subcellular actin structures with cell length through decelerated growth |
topic | Cell Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233038/ https://www.ncbi.nlm.nih.gov/pubmed/34114567 http://dx.doi.org/10.7554/eLife.68424 |
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