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Scaling of subcellular actin structures with cell length through decelerated growth

How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting...

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Detalles Bibliográficos
Autores principales: McInally, Shane G, Kondev, Jane, Goode, Bruce L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233038/
https://www.ncbi.nlm.nih.gov/pubmed/34114567
http://dx.doi.org/10.7554/eLife.68424
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author McInally, Shane G
Kondev, Jane
Goode, Bruce L
author_facet McInally, Shane G
Kondev, Jane
Goode, Bruce L
author_sort McInally, Shane G
collection PubMed
description How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a ‘balance-point’ model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell.
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spelling pubmed-82330382021-06-28 Scaling of subcellular actin structures with cell length through decelerated growth McInally, Shane G Kondev, Jane Goode, Bruce L eLife Cell Biology How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a ‘balance-point’ model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell. eLife Sciences Publications, Ltd 2021-06-11 /pmc/articles/PMC8233038/ /pubmed/34114567 http://dx.doi.org/10.7554/eLife.68424 Text en © 2021, McInally et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
McInally, Shane G
Kondev, Jane
Goode, Bruce L
Scaling of subcellular actin structures with cell length through decelerated growth
title Scaling of subcellular actin structures with cell length through decelerated growth
title_full Scaling of subcellular actin structures with cell length through decelerated growth
title_fullStr Scaling of subcellular actin structures with cell length through decelerated growth
title_full_unstemmed Scaling of subcellular actin structures with cell length through decelerated growth
title_short Scaling of subcellular actin structures with cell length through decelerated growth
title_sort scaling of subcellular actin structures with cell length through decelerated growth
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233038/
https://www.ncbi.nlm.nih.gov/pubmed/34114567
http://dx.doi.org/10.7554/eLife.68424
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