Cargando…

MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture

We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Victoria L., Johnson, Graham W., Cai, Leon Y., Landman, Bennett A., Schilling, Kurt G., Englot, Dario J., Rogers, Baxter P., Chang, Catie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MIT Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233120/
https://www.ncbi.nlm.nih.gov/pubmed/34189372
http://dx.doi.org/10.1162/netn_a_00184
_version_ 1783713781654749184
author Morgan, Victoria L.
Johnson, Graham W.
Cai, Leon Y.
Landman, Bennett A.
Schilling, Kurt G.
Englot, Dario J.
Rogers, Baxter P.
Chang, Catie
author_facet Morgan, Victoria L.
Johnson, Graham W.
Cai, Leon Y.
Landman, Bennett A.
Schilling, Kurt G.
Englot, Dario J.
Rogers, Baxter P.
Chang, Catie
author_sort Morgan, Victoria L.
collection PubMed
description We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region functional connectivity, structural connectivity, and streamline length connectomes per subject. Three models of distance from the presumed seizure focus in the anterior hippocampus in the healthy brain were computed using the average connectome across controls. A fourth model was defined using regions of transmodal (higher cognitive function) to unimodal (perceptual) networks across a published functional gradient in the healthy brain. These models were used to test whether network progression in patients increased when distance from the anterior hippocampus or along a functional gradient in the healthy brain decreases. Results showed that alterations of structural and functional networks in mTLE occur in greater magnitude in regions of the brain closer to the seizure focus based on healthy brain topology, and decrease as distance from the focus increases over duration of disease. Overall, this work provides evidence that changes across the brain in focal epilepsy occur along healthy brain architecture.
format Online
Article
Text
id pubmed-8233120
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MIT Press
record_format MEDLINE/PubMed
spelling pubmed-82331202021-06-28 MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture Morgan, Victoria L. Johnson, Graham W. Cai, Leon Y. Landman, Bennett A. Schilling, Kurt G. Englot, Dario J. Rogers, Baxter P. Chang, Catie Netw Neurosci Research Article We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region functional connectivity, structural connectivity, and streamline length connectomes per subject. Three models of distance from the presumed seizure focus in the anterior hippocampus in the healthy brain were computed using the average connectome across controls. A fourth model was defined using regions of transmodal (higher cognitive function) to unimodal (perceptual) networks across a published functional gradient in the healthy brain. These models were used to test whether network progression in patients increased when distance from the anterior hippocampus or along a functional gradient in the healthy brain decreases. Results showed that alterations of structural and functional networks in mTLE occur in greater magnitude in regions of the brain closer to the seizure focus based on healthy brain topology, and decrease as distance from the focus increases over duration of disease. Overall, this work provides evidence that changes across the brain in focal epilepsy occur along healthy brain architecture. MIT Press 2021-04-27 /pmc/articles/PMC8233120/ /pubmed/34189372 http://dx.doi.org/10.1162/netn_a_00184 Text en © 2021 Massachusetts Institute of Technology https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Morgan, Victoria L.
Johnson, Graham W.
Cai, Leon Y.
Landman, Bennett A.
Schilling, Kurt G.
Englot, Dario J.
Rogers, Baxter P.
Chang, Catie
MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title_full MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title_fullStr MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title_full_unstemmed MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title_short MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
title_sort mri network progression in mesial temporal lobe epilepsy related to healthy brain architecture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233120/
https://www.ncbi.nlm.nih.gov/pubmed/34189372
http://dx.doi.org/10.1162/netn_a_00184
work_keys_str_mv AT morganvictorial mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT johnsongrahamw mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT caileony mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT landmanbennetta mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT schillingkurtg mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT englotdarioj mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT rogersbaxterp mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture
AT changcatie mrinetworkprogressioninmesialtemporallobeepilepsyrelatedtohealthybrainarchitecture