Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress

We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the developmen...

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Detalles Bibliográficos
Autores principales: Dzikovskaya, L. A., Degtyareva, E. S., Shegai, P. V., Ivanov, S. A., Kaprin, A. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Biotechnologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233178/
https://www.ncbi.nlm.nih.gov/pubmed/34173103
http://dx.doi.org/10.1007/s10517-021-05204-5
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author Dzikovskaya, L. A.
Degtyareva, E. S.
Shegai, P. V.
Ivanov, S. A.
Kaprin, A. D.
author_facet Dzikovskaya, L. A.
Degtyareva, E. S.
Shegai, P. V.
Ivanov, S. A.
Kaprin, A. D.
author_sort Dzikovskaya, L. A.
collection PubMed
description We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic ОН· radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity.
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spelling pubmed-82331782021-06-28 Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress Dzikovskaya, L. A. Degtyareva, E. S. Shegai, P. V. Ivanov, S. A. Kaprin, A. D. Bull Exp Biol Med Biotechnologies We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic ОН· radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity. Springer US 2021-06-26 2021 /pmc/articles/PMC8233178/ /pubmed/34173103 http://dx.doi.org/10.1007/s10517-021-05204-5 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Biotechnologies
Dzikovskaya, L. A.
Degtyareva, E. S.
Shegai, P. V.
Ivanov, S. A.
Kaprin, A. D.
Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title_full Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title_fullStr Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title_full_unstemmed Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title_short Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress
title_sort antioxidant properties of a nanostructured clathrate complex selenopyran with β-cyclodextrin in model systems of oxidative stress
topic Biotechnologies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233178/
https://www.ncbi.nlm.nih.gov/pubmed/34173103
http://dx.doi.org/10.1007/s10517-021-05204-5
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