Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection

The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG an...

Descripción completa

Detalles Bibliográficos
Autores principales: Aleshkin, A. V., Novikova, L. I., Bochkareva, S. S., Kombarova, S. Yu., Lebedin, Yu. S., Vorob’ev, A. M., Mekhtiev, E. R., Zul’karneev, E. R., Laishevtsev, A. I., Karaulov, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233179/
https://www.ncbi.nlm.nih.gov/pubmed/34173107
http://dx.doi.org/10.1007/s10517-021-05200-9
Descripción
Sumario:The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.

Ejemplares similares