Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection

The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG an...

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Autores principales: Aleshkin, A. V., Novikova, L. I., Bochkareva, S. S., Kombarova, S. Yu., Lebedin, Yu. S., Vorob’ev, A. M., Mekhtiev, E. R., Zul’karneev, E. R., Laishevtsev, A. I., Karaulov, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233179/
https://www.ncbi.nlm.nih.gov/pubmed/34173107
http://dx.doi.org/10.1007/s10517-021-05200-9
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author Aleshkin, A. V.
Novikova, L. I.
Bochkareva, S. S.
Kombarova, S. Yu.
Lebedin, Yu. S.
Vorob’ev, A. M.
Mekhtiev, E. R.
Zul’karneev, E. R.
Laishevtsev, A. I.
Karaulov, A. V.
author_facet Aleshkin, A. V.
Novikova, L. I.
Bochkareva, S. S.
Kombarova, S. Yu.
Lebedin, Yu. S.
Vorob’ev, A. M.
Mekhtiev, E. R.
Zul’karneev, E. R.
Laishevtsev, A. I.
Karaulov, A. V.
author_sort Aleshkin, A. V.
collection PubMed
description The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.
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spelling pubmed-82331792021-06-28 Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection Aleshkin, A. V. Novikova, L. I. Bochkareva, S. S. Kombarova, S. Yu. Lebedin, Yu. S. Vorob’ev, A. M. Mekhtiev, E. R. Zul’karneev, E. R. Laishevtsev, A. I. Karaulov, A. V. Bull Exp Biol Med Article The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease. Springer US 2021-06-26 2021 /pmc/articles/PMC8233179/ /pubmed/34173107 http://dx.doi.org/10.1007/s10517-021-05200-9 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Aleshkin, A. V.
Novikova, L. I.
Bochkareva, S. S.
Kombarova, S. Yu.
Lebedin, Yu. S.
Vorob’ev, A. M.
Mekhtiev, E. R.
Zul’karneev, E. R.
Laishevtsev, A. I.
Karaulov, A. V.
Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title_full Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title_fullStr Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title_full_unstemmed Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title_short Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection
title_sort dynamics of antibodies to various antigens of the sars-cov-2 coronavirus in patients with confirmed covid-19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233179/
https://www.ncbi.nlm.nih.gov/pubmed/34173107
http://dx.doi.org/10.1007/s10517-021-05200-9
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