Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains. Here, we report that vector co-infusion with doxorubicin, a clinical anti-cancer drug, markedly enhanced rAAV-mediated transgene expression in t...

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Detalles Bibliográficos
Autores principales: Gong, Hongliang, Yuan, Nini, Shen, Zhiming, Tang, Cheng, Shipp, Stewart, Qian, Liling, Lu, Yiliang, Andolina, Ian Max, Zhang, Shenghai, Wu, Jihong, Yang, Hui, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233199/
https://www.ncbi.nlm.nih.gov/pubmed/34195565
http://dx.doi.org/10.1016/j.isci.2021.102685

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