Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway

OBJECTIVE: NLRP3 inflammasome may play a key role in OA pathogenesis. Stromal cell-derived factor-1 (SDF-1) is a homeostatic CXC chemokine. Since the role of SDF-1 in OA has not been explored, this study aimed to examine the effect of SDF-1 on NLRP3 inflammasome and pyroptosis in synoviocytes from O...

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Detalles Bibliográficos
Autores principales: Wang, Shuya, Mobasheri, Ali, Zhang, Yue, Wang, Yanli, Dai, Tianqi, Zhang, Zhiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233244/
https://www.ncbi.nlm.nih.gov/pubmed/34085175
http://dx.doi.org/10.1007/s10787-021-00814-x

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