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Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study

Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammator...

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Autores principales: Lombardi, Andrea, Duiella, Silvia, Li Piani, Letizia, Comelli, Agnese, Ceriotti, Ferruccio, Oggioni, Massimo, Muscatello, Antonio, Bandera, Alessandra, Gori, Andrea, Ferrazzi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233302/
https://www.ncbi.nlm.nih.gov/pubmed/34172816
http://dx.doi.org/10.1038/s41598-021-92885-7
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author Lombardi, Andrea
Duiella, Silvia
Li Piani, Letizia
Comelli, Agnese
Ceriotti, Ferruccio
Oggioni, Massimo
Muscatello, Antonio
Bandera, Alessandra
Gori, Andrea
Ferrazzi, Enrico
author_facet Lombardi, Andrea
Duiella, Silvia
Li Piani, Letizia
Comelli, Agnese
Ceriotti, Ferruccio
Oggioni, Massimo
Muscatello, Antonio
Bandera, Alessandra
Gori, Andrea
Ferrazzi, Enrico
author_sort Lombardi, Andrea
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammatory biomarkers and hemocytometry variables in a cohort of obstetric patients hospitalized with COVID-19 and we have correlated the values at admission with the need of oxygen supplementation during the hospitalization. Overall, among 62 (27.3%) pregnant women and 165 (72.7%) postpartum women, 21 (9.2%) patients received oxygen supplementation and 2 (0.9%) required admission to intensive care unit but none died. During hospitalization leukocytes (p < 0.001), neutrophils (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001) and C reactive protein (p < 0.001) decreased significantly, whereas lymphocytes (p < 0.001), platelets (p < 0.001) and ferritin (p = 0.001) increased. Lymphocyte values at admission were correlated with oxygen need, with a 26% higher risk of oxygen supplementation for each 1000 cells decreases. Overall, in obstetric patients hospitalized with COVID-19, C reactive protein is the inflammatory biomarker that better mirrors the course of the disease whereas D-dimer or ferritin are not reliable predictors of poor outcome. Care to the need of oxygen supplementation should be reserved to patients with reduced lymphocyte values at admission.
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spelling pubmed-82333022021-07-02 Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study Lombardi, Andrea Duiella, Silvia Li Piani, Letizia Comelli, Agnese Ceriotti, Ferruccio Oggioni, Massimo Muscatello, Antonio Bandera, Alessandra Gori, Andrea Ferrazzi, Enrico Sci Rep Article Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammatory biomarkers and hemocytometry variables in a cohort of obstetric patients hospitalized with COVID-19 and we have correlated the values at admission with the need of oxygen supplementation during the hospitalization. Overall, among 62 (27.3%) pregnant women and 165 (72.7%) postpartum women, 21 (9.2%) patients received oxygen supplementation and 2 (0.9%) required admission to intensive care unit but none died. During hospitalization leukocytes (p < 0.001), neutrophils (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001) and C reactive protein (p < 0.001) decreased significantly, whereas lymphocytes (p < 0.001), platelets (p < 0.001) and ferritin (p = 0.001) increased. Lymphocyte values at admission were correlated with oxygen need, with a 26% higher risk of oxygen supplementation for each 1000 cells decreases. Overall, in obstetric patients hospitalized with COVID-19, C reactive protein is the inflammatory biomarker that better mirrors the course of the disease whereas D-dimer or ferritin are not reliable predictors of poor outcome. Care to the need of oxygen supplementation should be reserved to patients with reduced lymphocyte values at admission. Nature Publishing Group UK 2021-06-25 /pmc/articles/PMC8233302/ /pubmed/34172816 http://dx.doi.org/10.1038/s41598-021-92885-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lombardi, Andrea
Duiella, Silvia
Li Piani, Letizia
Comelli, Agnese
Ceriotti, Ferruccio
Oggioni, Massimo
Muscatello, Antonio
Bandera, Alessandra
Gori, Andrea
Ferrazzi, Enrico
Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_full Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_fullStr Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_full_unstemmed Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_short Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_sort inflammatory biomarkers in pregnant women with covid-19: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233302/
https://www.ncbi.nlm.nih.gov/pubmed/34172816
http://dx.doi.org/10.1038/s41598-021-92885-7
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