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Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233305/ https://www.ncbi.nlm.nih.gov/pubmed/34172805 http://dx.doi.org/10.1038/s41598-021-92945-y |
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author | Lacombe, Valentin Chabrun, Floris Lacout, Carole Ghali, Alaa Capitain, Olivier Patsouris, Anne Lavigne, Christian Urbanski, Geoffrey |
author_facet | Lacombe, Valentin Chabrun, Floris Lacout, Carole Ghali, Alaa Capitain, Olivier Patsouris, Anne Lavigne, Christian Urbanski, Geoffrey |
author_sort | Lacombe, Valentin |
collection | PubMed |
description | Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest. |
format | Online Article Text |
id | pubmed-8233305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82333052021-07-02 Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer Lacombe, Valentin Chabrun, Floris Lacout, Carole Ghali, Alaa Capitain, Olivier Patsouris, Anne Lavigne, Christian Urbanski, Geoffrey Sci Rep Article Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest. Nature Publishing Group UK 2021-06-25 /pmc/articles/PMC8233305/ /pubmed/34172805 http://dx.doi.org/10.1038/s41598-021-92945-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lacombe, Valentin Chabrun, Floris Lacout, Carole Ghali, Alaa Capitain, Olivier Patsouris, Anne Lavigne, Christian Urbanski, Geoffrey Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title | Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_full | Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_fullStr | Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_full_unstemmed | Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_short | Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_sort | persistent elevation of plasma vitamin b12 is strongly associated with solid cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233305/ https://www.ncbi.nlm.nih.gov/pubmed/34172805 http://dx.doi.org/10.1038/s41598-021-92945-y |
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