Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose its aggregation-prone hydrophobic core, prompting se...

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Detalles Bibliográficos
Autores principales: Palanikumar, L., Karpauskaite, Laura, Al-Sayegh, Mohamed, Chehade, Ibrahim, Alam, Maheen, Hassan, Sarah, Maity, Debabrata, Ali, Liaqat, Kalmouni, Mona, Hunashal, Yamanappa, Ahmed, Jemil, Houhou, Tatiana, Karapetyan, Shake, Falls, Zackary, Samudrala, Ram, Pasricha, Renu, Esposito, Gennaro, Afzal, Ahmed J., Hamilton, Andrew D., Kumar, Sunil, Magzoub, Mazin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233319/
https://www.ncbi.nlm.nih.gov/pubmed/34172723
http://dx.doi.org/10.1038/s41467-021-23985-1

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