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Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia

The presence of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and is associated with an unfavorable prognosis. FLT3 inhibitors, such as midostaurin, are used clinically but fail to entirely eradicate FLT3-ITD +...

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Detalles Bibliográficos
Autores principales:	Garitano-Trojaola, Andoni, Sancho, Ana, Götz, Ralph, Eiring, Patrick, Walz, Susanne, Jetani, Hardikkumar, Gil-Pulido, Jesus, Da Via, Matteo Claudio, Teufel, Eva, Rhodes, Nadine, Haertle, Larissa, Arellano-Viera, Estibaliz, Tibes, Raoul, Rosenwald, Andreas, Rasche, Leo, Hudecek, Michael, Sauer, Markus, Groll, Jürgen, Einsele, Hermann, Kraus, Sabrina, Kortüm, Martin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233337/ https://www.ncbi.nlm.nih.gov/pubmed/34172833 http://dx.doi.org/10.1038/s42003-021-02215-w

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