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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation, resulting in phosphorylation of the central NMD factor UPF1 and robust clearance of NMD targets via two seemingly indep...

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Detalles Bibliográficos
Autores principales:	Boehm, Volker, Kueckelmann, Sabrina, Gerbracht, Jennifer V., Kallabis, Sebastian, Britto-Borges, Thiago, Altmüller, Janine, Krüger, Marcus, Dieterich, Christoph, Gehring, Niels H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233366/ https://www.ncbi.nlm.nih.gov/pubmed/34172724 http://dx.doi.org/10.1038/s41467-021-24046-3

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