TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC is characterised by abundant CAFs and tumour necrosis factor-α (TNF-α). Here, we show that TNF-α strongly induces human endothelial cells to undergo E...

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Detalles Bibliográficos
Autores principales: Adjuto-Saccone, Marjorie, Soubeyran, Philippe, Garcia, Julie, Audebert, Stéphane, Camoin, Luc, Rubis, Marion, Roques, Julie, Binétruy, Bernard, Iovanna, Juan Lucio, Tournaire, Roselyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233393/
https://www.ncbi.nlm.nih.gov/pubmed/34172716
http://dx.doi.org/10.1038/s41419-021-03920-4

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