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Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of ra...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233419/ https://www.ncbi.nlm.nih.gov/pubmed/34172787 http://dx.doi.org/10.1038/s41598-021-92587-0 |
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author | Blanco-Pérez, José Jesús Blanco-Dorado, Sara Rodríguez-García, Javier Gonzalez-Bello, Mª Elena Salgado-Barreira, Ángel Caldera-Díaz, Adriana Carolina Pallarés-Sanmartín, Abel Fernandez-Villar, Alberto González-Barcala, Francisco Javier |
author_facet | Blanco-Pérez, José Jesús Blanco-Dorado, Sara Rodríguez-García, Javier Gonzalez-Bello, Mª Elena Salgado-Barreira, Ángel Caldera-Díaz, Adriana Carolina Pallarés-Sanmartín, Abel Fernandez-Villar, Alberto González-Barcala, Francisco Javier |
author_sort | Blanco-Pérez, José Jesús |
collection | PubMed |
description | Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality. |
format | Online Article Text |
id | pubmed-8233419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82334192021-07-06 Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers Blanco-Pérez, José Jesús Blanco-Dorado, Sara Rodríguez-García, Javier Gonzalez-Bello, Mª Elena Salgado-Barreira, Ángel Caldera-Díaz, Adriana Carolina Pallarés-Sanmartín, Abel Fernandez-Villar, Alberto González-Barcala, Francisco Javier Sci Rep Article Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality. Nature Publishing Group UK 2021-06-25 /pmc/articles/PMC8233419/ /pubmed/34172787 http://dx.doi.org/10.1038/s41598-021-92587-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Blanco-Pérez, José Jesús Blanco-Dorado, Sara Rodríguez-García, Javier Gonzalez-Bello, Mª Elena Salgado-Barreira, Ángel Caldera-Díaz, Adriana Carolina Pallarés-Sanmartín, Abel Fernandez-Villar, Alberto González-Barcala, Francisco Javier Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title | Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title_full | Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title_fullStr | Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title_full_unstemmed | Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title_short | Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
title_sort | serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233419/ https://www.ncbi.nlm.nih.gov/pubmed/34172787 http://dx.doi.org/10.1038/s41598-021-92587-0 |
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