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Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease

Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial impairment. The coenzyme nicotinamide adenine dinucleotide (NAD(+)) is essentia...

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Detalles Bibliográficos
Autores principales:	Yu, Yizhou, Fedele, Giorgio, Celardo, Ivana, Loh, Samantha H. Y., Martins, L. Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233423/ https://www.ncbi.nlm.nih.gov/pubmed/34172715 http://dx.doi.org/10.1038/s41419-021-03926-y

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