Cargando…

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

There are, besides remdesivir, no approved antivirals for the treatment of SARS-CoV-2 infections. To aid in the search for antivirals against this virus, we explored the use of human tracheal airway epithelial cells (HtAEC) and human small airway epithelial cells (HsAEC) grown at the air-liquid inte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Do, Thuc Nguyen Dan, Donckers, Kim, Vangeel, Laura, Chatterjee, Arnab K., Gallay, Philippe A., Bobardt, Michael D., Bilello, John P., Cihlar, Tomas, De Jonghe, Steven, Neyts, Johan, Jochmans, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233549/ https://www.ncbi.nlm.nih.gov/pubmed/34186107 http://dx.doi.org/10.1016/j.antiviral.2021.105122

Ejemplares similares

Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery
por: Chiu, Winston, et al.
Publicado: (2023)

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase
por: Kasprzyk, Renata, et al.
Publicado: (2021)

Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model
por: Foo, Caroline S., et al.
Publicado: (2022)

The path towards effective antivirals against rabies
por: Jochmans, Dirk, et al.
Publicado: (2019)

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model
por: Abdelnabi, Rana, et al.
Publicado: (2021)

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues
por: Persoons, Leentje, et al.
Publicado: (2021)

Intervention strategies for emerging viruses: use of antivirals
por: Debing, Yannick, et al.
Publicado: (2013)

Norovirus: Targets and tools in antiviral drug discovery
por: Rocha-Pereira, Joana, et al.
Publicado: (2014)

Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment
por: Abdelnabi, Rana, et al.
Publicado: (2023)

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
por: Vangeel, Laura, et al.
Publicado: (2022)

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE
por: Jochmans, Dirk, et al.
Publicado: (2012)

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells
por: Vanhoutte, Roeland, et al.
Publicado: (2023)

Both Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells
por: Bobardt, Michael, et al.
Publicado: (2014)

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral Activity
por: Stauffer, Winston, et al.
Publicado: (2023)

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity
por: Stauffer, Winston, et al.
Publicado: (2023)

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication
por: Bardiot, Dorothée, et al.
Publicado: (2022)

SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells
por: Do, Thuc Nguyen Dan, et al.
Publicado: (2022)

HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect
por: Foo, Caroline S., et al.
Publicado: (2022)

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
por: Jochmans, Dirk, et al.
Publicado: (2023)

Sustaining Robust Cavities with Slippery Liquid–Liquid Interfaces
por: Zhu, Suwan, et al.
Publicado: (2022)

A Novel Method—Amenable for High-throughput Screening Purposes—to Quantify Antiviral Activity Against Viruses that Induce Limited CPE
por: Jochmans, Dirk, et al.
Publicado: (2011)

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives
por: El Mansouri, Az-eddine, et al.
Publicado: (2022)

Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents
por: Martinez-Gualda, Belén, et al.
Publicado: (2022)

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
por: Gao, Shenghua, et al.
Publicado: (2022)

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium
por: Mirabelli, Carmen, et al.
Publicado: (2018)

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals
por: Escaffre, Olivier, et al.
Publicado: (2023)

Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production
por: Phillips, Sandra, et al.
Publicado: (2015)

Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
por: Cubero, Meritxell, et al.
Publicado: (2019)

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Toxicity of Silver Nanoparticles at the Air-Liquid Interface
por: Holder, Amara L., et al.
Publicado: (2013)

Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro
por: Paull, Jeremy R.A., et al.
Publicado: (2021)

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A
por: Coelmont, Lotte, et al.
Publicado: (2010)

Biofilm formation at the solid-liquid and air-liquid interfaces by Acinetobacter species
por: Martí, Sara, et al.
Publicado: (2011)

Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
por: Brackley, C. A., et al.
Publicado: (2021)

Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
por: Nizi, Maria Giulia, et al.
Publicado: (2022)

Shaping Liquid Droplets on an Active Air–Ferrofluid Interface
por: Harischandra, P. A. Diluka, et al.
Publicado: (2023)

Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions
por: Tauber, Carolin, et al.
Publicado: (2021)

Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface
por: Wang, Wenda, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_da1fdudo55gvu1c9urvst78v1d