CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in neuroblastoma. Using RNA sequencing (RNA-seq) analysis, we sh...

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Detalles Bibliográficos
Autores principales: Li, Nan, Torres, Madeline B., Spetz, Madeline R., Wang, Ruixue, Peng, Luyi, Tian, Meijie, Dower, Christopher M., Nguyen, Rosa, Sun, Ming, Tai, Chin-Hsien, de Val, Natalia, Cachau, Raul, Wu, Xiaolin, Hewitt, Stephen M., Kaplan, Rosandra N., Khan, Javed, St Croix, Brad, Thiele, Carol J., Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233664/
https://www.ncbi.nlm.nih.gov/pubmed/34195677
http://dx.doi.org/10.1016/j.xcrm.2021.100297

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