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Furanocoumarins from Ruta chalepensis with Amebicide Activity

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment h...

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Autores principales: Bazaldúa-Rodríguez, Aldo Fabio, Quintanilla-Licea, Ramiro, Verde-Star, María Julia, Hernández-García, Magda Elizabeth, Vargas-Villarreal, Javier, Garza-González, Jesús Norberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233766/
https://www.ncbi.nlm.nih.gov/pubmed/34208750
http://dx.doi.org/10.3390/molecules26123684
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author Bazaldúa-Rodríguez, Aldo Fabio
Quintanilla-Licea, Ramiro
Verde-Star, María Julia
Hernández-García, Magda Elizabeth
Vargas-Villarreal, Javier
Garza-González, Jesús Norberto
author_facet Bazaldúa-Rodríguez, Aldo Fabio
Quintanilla-Licea, Ramiro
Verde-Star, María Julia
Hernández-García, Magda Elizabeth
Vargas-Villarreal, Javier
Garza-González, Jesús Norberto
author_sort Bazaldúa-Rodríguez, Aldo Fabio
collection PubMed
description Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC(50) values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.
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spelling pubmed-82337662021-06-27 Furanocoumarins from Ruta chalepensis with Amebicide Activity Bazaldúa-Rodríguez, Aldo Fabio Quintanilla-Licea, Ramiro Verde-Star, María Julia Hernández-García, Magda Elizabeth Vargas-Villarreal, Javier Garza-González, Jesús Norberto Molecules Article Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC(50) values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin. MDPI 2021-06-16 /pmc/articles/PMC8233766/ /pubmed/34208750 http://dx.doi.org/10.3390/molecules26123684 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bazaldúa-Rodríguez, Aldo Fabio
Quintanilla-Licea, Ramiro
Verde-Star, María Julia
Hernández-García, Magda Elizabeth
Vargas-Villarreal, Javier
Garza-González, Jesús Norberto
Furanocoumarins from Ruta chalepensis with Amebicide Activity
title Furanocoumarins from Ruta chalepensis with Amebicide Activity
title_full Furanocoumarins from Ruta chalepensis with Amebicide Activity
title_fullStr Furanocoumarins from Ruta chalepensis with Amebicide Activity
title_full_unstemmed Furanocoumarins from Ruta chalepensis with Amebicide Activity
title_short Furanocoumarins from Ruta chalepensis with Amebicide Activity
title_sort furanocoumarins from ruta chalepensis with amebicide activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233766/
https://www.ncbi.nlm.nih.gov/pubmed/34208750
http://dx.doi.org/10.3390/molecules26123684
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