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The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora

Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on th...

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Detalles Bibliográficos
Autores principales: Zhang, Zhicheng, Zhang, Yuting, Li, Junmin, Fu, Chengxin, Zhang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233780/
https://www.ncbi.nlm.nih.gov/pubmed/34204244
http://dx.doi.org/10.3390/molecules26123692
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author Zhang, Zhicheng
Zhang, Yuting
Li, Junmin
Fu, Chengxin
Zhang, Xin
author_facet Zhang, Zhicheng
Zhang, Yuting
Li, Junmin
Fu, Chengxin
Zhang, Xin
author_sort Zhang, Zhicheng
collection PubMed
description Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the “microflora–gut–brain axis”, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe–gut–brain axis) occurs through a variety of pathways, including the vagus nerve, immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and behavior, which is usually associated with neuropsychiatric disorders. In this review, we discuss that TPs and their metabolites may provide benefits by restoring the imbalance of intestinal microbiota and that TPs are metabolized by intestinal flora, to provide a new idea for TPs to play a neuroprotective role by regulating intestinal flora.
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spelling pubmed-82337802021-06-27 The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora Zhang, Zhicheng Zhang, Yuting Li, Junmin Fu, Chengxin Zhang, Xin Molecules Review Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the “microflora–gut–brain axis”, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe–gut–brain axis) occurs through a variety of pathways, including the vagus nerve, immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and behavior, which is usually associated with neuropsychiatric disorders. In this review, we discuss that TPs and their metabolites may provide benefits by restoring the imbalance of intestinal microbiota and that TPs are metabolized by intestinal flora, to provide a new idea for TPs to play a neuroprotective role by regulating intestinal flora. MDPI 2021-06-17 /pmc/articles/PMC8233780/ /pubmed/34204244 http://dx.doi.org/10.3390/molecules26123692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Zhicheng
Zhang, Yuting
Li, Junmin
Fu, Chengxin
Zhang, Xin
The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title_full The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title_fullStr The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title_full_unstemmed The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title_short The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
title_sort neuroprotective effect of tea polyphenols on the regulation of intestinal flora
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233780/
https://www.ncbi.nlm.nih.gov/pubmed/34204244
http://dx.doi.org/10.3390/molecules26123692
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