Cargando…

Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients

Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the ris...

Descripción completa

Detalles Bibliográficos
Autores principales: Tu, Min-Yu, Han, Kuei-Yang, Lan, Ying-Wei, Chang, Ku-Yi, Lai, Cheng-Wei, Staniczek, Theresa, Lai, Chung-Yu, Chong, Kowit-Yu, Chen, Chuan-Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233820/
https://www.ncbi.nlm.nih.gov/pubmed/34207210
http://dx.doi.org/10.3390/genes12060930
_version_ 1783713938410569728
author Tu, Min-Yu
Han, Kuei-Yang
Lan, Ying-Wei
Chang, Ku-Yi
Lai, Cheng-Wei
Staniczek, Theresa
Lai, Chung-Yu
Chong, Kowit-Yu
Chen, Chuan-Mu
author_facet Tu, Min-Yu
Han, Kuei-Yang
Lan, Ying-Wei
Chang, Ku-Yi
Lai, Cheng-Wei
Staniczek, Theresa
Lai, Chung-Yu
Chong, Kowit-Yu
Chen, Chuan-Mu
author_sort Tu, Min-Yu
collection PubMed
description Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.
format Online
Article
Text
id pubmed-8233820
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82338202021-06-27 Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients Tu, Min-Yu Han, Kuei-Yang Lan, Ying-Wei Chang, Ku-Yi Lai, Cheng-Wei Staniczek, Theresa Lai, Chung-Yu Chong, Kowit-Yu Chen, Chuan-Mu Genes (Basel) Article Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. MDPI 2021-06-18 /pmc/articles/PMC8233820/ /pubmed/34207210 http://dx.doi.org/10.3390/genes12060930 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tu, Min-Yu
Han, Kuei-Yang
Lan, Ying-Wei
Chang, Ku-Yi
Lai, Cheng-Wei
Staniczek, Theresa
Lai, Chung-Yu
Chong, Kowit-Yu
Chen, Chuan-Mu
Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title_full Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title_fullStr Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title_full_unstemmed Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title_short Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
title_sort association of tgf-β1 and il-10 gene polymorphisms with osteoporosis in a study of taiwanese osteoporotic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233820/
https://www.ncbi.nlm.nih.gov/pubmed/34207210
http://dx.doi.org/10.3390/genes12060930
work_keys_str_mv AT tuminyu associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT hankueiyang associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT lanyingwei associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT changkuyi associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT laichengwei associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT staniczektheresa associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT laichungyu associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT chongkowityu associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients
AT chenchuanmu associationoftgfb1andil10genepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients