Cargando…
Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis
Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA), including sclerotic changes, cystic lesions, and osteophyte formation. Osteocytes act as mechanosensory units for the micro-cracks in response to mechanical loading. Once stimulated, osteocytes initiate the repara...
Autores principales: | Zhang, Lanlan, Wen, Chunyi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233862/ https://www.ncbi.nlm.nih.gov/pubmed/34204587 http://dx.doi.org/10.3390/ijms22126522 |
Ejemplares similares
-
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
por: Mazur, Courtney M., et al.
Publicado: (2019) -
NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
por: Sánchez-de-Diego, Cristina, et al.
Publicado: (2020) -
COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives
por: Lauwers, Marianne, et al.
Publicado: (2022) -
The crucial role of osteocyte-derived RANKL in bone homeostasis
por: Nakashima, Tomoki, et al.
Publicado: (2012) -
Molecular mechanosensors in osteocytes
por: Qin, Lei, et al.
Publicado: (2020)