Cargando…
Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level
SIMPLE SUMMARY: Soft tissue sarcoma is a rare mesenchymal malignancy. Despite the advancements in the fields of radiology, pathology and surgery, these tumors often recur locally and/or with metastatic disease. STS is considered to be a diagnostic challenge due to the large variety of histological s...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233868/ https://www.ncbi.nlm.nih.gov/pubmed/34207243 http://dx.doi.org/10.3390/cancers13123044 |
_version_ | 1783713949834805248 |
---|---|
author | Pillozzi, Serena Bernini, Andrea Palchetti, Ilaria Crociani, Olivia Antonuzzo, Lorenzo Campanacci, Domenico Scoccianti, Guido |
author_facet | Pillozzi, Serena Bernini, Andrea Palchetti, Ilaria Crociani, Olivia Antonuzzo, Lorenzo Campanacci, Domenico Scoccianti, Guido |
author_sort | Pillozzi, Serena |
collection | PubMed |
description | SIMPLE SUMMARY: Soft tissue sarcoma is a rare mesenchymal malignancy. Despite the advancements in the fields of radiology, pathology and surgery, these tumors often recur locally and/or with metastatic disease. STS is considered to be a diagnostic challenge due to the large variety of histological subtypes with clinical and histopathological characteristics which are not always distinct. One of the important clinical problems is a lack of useful biomarkers. Therefore, the discovery of biomarkers that can be used to detect tumors or predict tumor response to chemotherapy or radiotherapy could help clinicians provide more effective clinical management. ABSTRACT: Soft tissue sarcomas (STSs) are a heterogeneous group of rare tumors. Although constituting only 1% of all human malignancies, STSs represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. Over 100 histologic subtypes have been characterized to date (occurring predominantly in the trunk, extremity, and retroperitoneum), and many more are being discovered due to molecular profiling. STS mortality remains high, despite adjuvant chemotherapy. New prognostic stratification markers are needed to help identify patients at risk of recurrence and possibly apply more intensive or novel treatments. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the most relevant cellular, molecular and metabolic biomarkers for STS, and highlight advances in STS-related biomarker research. |
format | Online Article Text |
id | pubmed-8233868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82338682021-06-27 Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level Pillozzi, Serena Bernini, Andrea Palchetti, Ilaria Crociani, Olivia Antonuzzo, Lorenzo Campanacci, Domenico Scoccianti, Guido Cancers (Basel) Review SIMPLE SUMMARY: Soft tissue sarcoma is a rare mesenchymal malignancy. Despite the advancements in the fields of radiology, pathology and surgery, these tumors often recur locally and/or with metastatic disease. STS is considered to be a diagnostic challenge due to the large variety of histological subtypes with clinical and histopathological characteristics which are not always distinct. One of the important clinical problems is a lack of useful biomarkers. Therefore, the discovery of biomarkers that can be used to detect tumors or predict tumor response to chemotherapy or radiotherapy could help clinicians provide more effective clinical management. ABSTRACT: Soft tissue sarcomas (STSs) are a heterogeneous group of rare tumors. Although constituting only 1% of all human malignancies, STSs represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. Over 100 histologic subtypes have been characterized to date (occurring predominantly in the trunk, extremity, and retroperitoneum), and many more are being discovered due to molecular profiling. STS mortality remains high, despite adjuvant chemotherapy. New prognostic stratification markers are needed to help identify patients at risk of recurrence and possibly apply more intensive or novel treatments. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the most relevant cellular, molecular and metabolic biomarkers for STS, and highlight advances in STS-related biomarker research. MDPI 2021-06-18 /pmc/articles/PMC8233868/ /pubmed/34207243 http://dx.doi.org/10.3390/cancers13123044 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pillozzi, Serena Bernini, Andrea Palchetti, Ilaria Crociani, Olivia Antonuzzo, Lorenzo Campanacci, Domenico Scoccianti, Guido Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title | Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title_full | Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title_fullStr | Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title_full_unstemmed | Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title_short | Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level |
title_sort | soft tissue sarcoma: an insight on biomarkers at molecular, metabolic and cellular level |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233868/ https://www.ncbi.nlm.nih.gov/pubmed/34207243 http://dx.doi.org/10.3390/cancers13123044 |
work_keys_str_mv | AT pillozziserena softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT berniniandrea softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT palchettiilaria softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT crocianiolivia softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT antonuzzolorenzo softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT campanaccidomenico softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel AT scocciantiguido softtissuesarcomaaninsightonbiomarkersatmolecularmetabolicandcellularlevel |