Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness

The p53 protein is one of the most important tumor suppressors that are frequently inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated or deleted, or due to the p53 protein inhibition by endogenous negative regulators, particularly murine double minute (MDM)...

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Detalles Bibliográficos
Autores principales: Moreira, Joana, Almeida, Joana, Saraiva, Lucília, Cidade, Honorina, Pinto, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233907/
https://www.ncbi.nlm.nih.gov/pubmed/34205272
http://dx.doi.org/10.3390/molecules26123737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233907/
https://www.ncbi.nlm.nih.gov/pubmed/34205272
http://dx.doi.org/10.3390/molecules26123737

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