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Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study

MR relaxometry increasingly contributes to liver imaging. Studies on native relaxation times mainly describe relation to the presence of fibrosis. The hypothesis was that relaxation times are also influenced by other inherent factors, including changes in liver synthesis function. With the approval...

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Autores principales: Fahlenkamp, Ute Lina, Kunkel, Jan, Ziegeler, Katharina, Neumann, Konrad, Adams, Lisa Christine, Engel, Günther, Böker, Sarah Maria, Makowski, Marcus Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233916/
https://www.ncbi.nlm.nih.gov/pubmed/34203008
http://dx.doi.org/10.3390/diagnostics11061125
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author Fahlenkamp, Ute Lina
Kunkel, Jan
Ziegeler, Katharina
Neumann, Konrad
Adams, Lisa Christine
Engel, Günther
Böker, Sarah Maria
Makowski, Marcus Richard
author_facet Fahlenkamp, Ute Lina
Kunkel, Jan
Ziegeler, Katharina
Neumann, Konrad
Adams, Lisa Christine
Engel, Günther
Böker, Sarah Maria
Makowski, Marcus Richard
author_sort Fahlenkamp, Ute Lina
collection PubMed
description MR relaxometry increasingly contributes to liver imaging. Studies on native relaxation times mainly describe relation to the presence of fibrosis. The hypothesis was that relaxation times are also influenced by other inherent factors, including changes in liver synthesis function. With the approval of the local ethics committee and written informed consent, data from 94 patients referred for liver MR imaging, of which 20 patients had cirrhosis, were included. Additionally to standard sequences, both native T1 and T2 parametric maps and T1 maps in the hepatobiliary phase of gadoxetate disodium were acquired. Associations with laboratory variables were assessed. Altogether, there was a negative correlation between albumin and all acquired relaxation times in cirrhotic patients. In non-cirrhotic patients, only T1 values exhibited a negative correlation with albumin. In all patients, bilirubin correlated significantly with post-contrast T1 relaxation times, whereas native relaxation times correlated only in cirrhotic patients. Evaluating patients with pathological INR values, post-contrast relaxation times were significantly higher, whereas native relaxation times did not correlate. In conclusion, apart from confirming the value of hepatobiliary phase T1 mapping, our results show a correlation of native T1 with serum albumin even in non-cirrhotic liver parenchyma, suggesting a direct influence of liver’s synthesis capacity on T1 relaxation times.
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spelling pubmed-82339162021-06-27 Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study Fahlenkamp, Ute Lina Kunkel, Jan Ziegeler, Katharina Neumann, Konrad Adams, Lisa Christine Engel, Günther Böker, Sarah Maria Makowski, Marcus Richard Diagnostics (Basel) Article MR relaxometry increasingly contributes to liver imaging. Studies on native relaxation times mainly describe relation to the presence of fibrosis. The hypothesis was that relaxation times are also influenced by other inherent factors, including changes in liver synthesis function. With the approval of the local ethics committee and written informed consent, data from 94 patients referred for liver MR imaging, of which 20 patients had cirrhosis, were included. Additionally to standard sequences, both native T1 and T2 parametric maps and T1 maps in the hepatobiliary phase of gadoxetate disodium were acquired. Associations with laboratory variables were assessed. Altogether, there was a negative correlation between albumin and all acquired relaxation times in cirrhotic patients. In non-cirrhotic patients, only T1 values exhibited a negative correlation with albumin. In all patients, bilirubin correlated significantly with post-contrast T1 relaxation times, whereas native relaxation times correlated only in cirrhotic patients. Evaluating patients with pathological INR values, post-contrast relaxation times were significantly higher, whereas native relaxation times did not correlate. In conclusion, apart from confirming the value of hepatobiliary phase T1 mapping, our results show a correlation of native T1 with serum albumin even in non-cirrhotic liver parenchyma, suggesting a direct influence of liver’s synthesis capacity on T1 relaxation times. MDPI 2021-06-20 /pmc/articles/PMC8233916/ /pubmed/34203008 http://dx.doi.org/10.3390/diagnostics11061125 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fahlenkamp, Ute Lina
Kunkel, Jan
Ziegeler, Katharina
Neumann, Konrad
Adams, Lisa Christine
Engel, Günther
Böker, Sarah Maria
Makowski, Marcus Richard
Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title_full Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title_fullStr Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title_full_unstemmed Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title_short Correlation of Native Liver Parenchyma T1 and T2 Relaxation Times and Liver Synthetic Function Tests: A Pilot Study
title_sort correlation of native liver parenchyma t1 and t2 relaxation times and liver synthetic function tests: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233916/
https://www.ncbi.nlm.nih.gov/pubmed/34203008
http://dx.doi.org/10.3390/diagnostics11061125
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