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Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers
Semen analysis is usually the first step in the assessment of male fertility. Although analyzes provide valuable information about male fertility, success of cytoplasmic sperm injection using this method is not predictable. In the recent years, studies have shown that sperm quality assessment helps...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233923/ https://www.ncbi.nlm.nih.gov/pubmed/34155862 http://dx.doi.org/10.22074/IJFS.2021.134602 |
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author | Aliakbari, Fereshteh Eshghifar, Nahal Mirfakhraie, Reza Pourghorban, Parisa Azizi, Faezeh |
author_facet | Aliakbari, Fereshteh Eshghifar, Nahal Mirfakhraie, Reza Pourghorban, Parisa Azizi, Faezeh |
author_sort | Aliakbari, Fereshteh |
collection | PubMed |
description | Semen analysis is usually the first step in the assessment of male fertility. Although analyzes provide valuable information about male fertility, success of cytoplasmic sperm injection using this method is not predictable. In the recent years, studies have shown that sperm quality assessment helps clinicians predict male fertility status based on the expression of biomarkers. To write this article, a comprehensive study was conducted on several RNA transcripts by searching related words on medical information databases by 2018. According to the literature, spermatogenesis based disorders in male infertility have a significant relationship with the expression level of some RNA molecules (like DAZ and PRM1/PRM2 ratio) in semen and testicular tissue. Thus, they might be used as predictor biomarkers to evaluate success rate of testicular sperm extraction (TESE) procedure, but confirmation of this hypothesis requires more extensive research. By comparing the number of RNAs attributed to each fertility disorder in men, it is possible to trace the causes of disease or return fertility to some infertile patients by regulating the mentioned molecules. Further researches can provide a better understanding of the use of RNA expression profiles in the diagnosis and treatment of male infertility. |
format | Online Article Text |
id | pubmed-8233923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-82339232021-07-01 Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers Aliakbari, Fereshteh Eshghifar, Nahal Mirfakhraie, Reza Pourghorban, Parisa Azizi, Faezeh Int J Fertil Steril Review Article Semen analysis is usually the first step in the assessment of male fertility. Although analyzes provide valuable information about male fertility, success of cytoplasmic sperm injection using this method is not predictable. In the recent years, studies have shown that sperm quality assessment helps clinicians predict male fertility status based on the expression of biomarkers. To write this article, a comprehensive study was conducted on several RNA transcripts by searching related words on medical information databases by 2018. According to the literature, spermatogenesis based disorders in male infertility have a significant relationship with the expression level of some RNA molecules (like DAZ and PRM1/PRM2 ratio) in semen and testicular tissue. Thus, they might be used as predictor biomarkers to evaluate success rate of testicular sperm extraction (TESE) procedure, but confirmation of this hypothesis requires more extensive research. By comparing the number of RNAs attributed to each fertility disorder in men, it is possible to trace the causes of disease or return fertility to some infertile patients by regulating the mentioned molecules. Further researches can provide a better understanding of the use of RNA expression profiles in the diagnosis and treatment of male infertility. Royan Institute 2021 2021-06-22 /pmc/articles/PMC8233923/ /pubmed/34155862 http://dx.doi.org/10.22074/IJFS.2021.134602 Text en The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aliakbari, Fereshteh Eshghifar, Nahal Mirfakhraie, Reza Pourghorban, Parisa Azizi, Faezeh Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title | Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title_full | Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title_fullStr | Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title_full_unstemmed | Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title_short | Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers |
title_sort | coding and non-coding rnas, as male fertility and infertility biomarkers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233923/ https://www.ncbi.nlm.nih.gov/pubmed/34155862 http://dx.doi.org/10.22074/IJFS.2021.134602 |
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