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Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus

(1) Background: The correlation between titers of islet autoantibodies (IAbs) and the loss of transplanted islets remains controversial. We sought to evaluate the prognostic utility of monitoring IAbs in diabetic patients after islet transplantation (ITx); (2) Methods: Twelve patients with Type 1 di...

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Autores principales: Anteby, Roi, Lucander, Aaron, Bachul, Piotr J., Pyda, Jordan, Grybowski, Damian, Basto, Lindsay, Generette, Gabriela S., Perea, Laurencia, Golab, Karolina, Wang, Ling-jia, Tibudan, Martin, Thomas, Celeste, Fung, John, Witkowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233942/
https://www.ncbi.nlm.nih.gov/pubmed/34205321
http://dx.doi.org/10.3390/jcm10122708
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author Anteby, Roi
Lucander, Aaron
Bachul, Piotr J.
Pyda, Jordan
Grybowski, Damian
Basto, Lindsay
Generette, Gabriela S.
Perea, Laurencia
Golab, Karolina
Wang, Ling-jia
Tibudan, Martin
Thomas, Celeste
Fung, John
Witkowski, Piotr
author_facet Anteby, Roi
Lucander, Aaron
Bachul, Piotr J.
Pyda, Jordan
Grybowski, Damian
Basto, Lindsay
Generette, Gabriela S.
Perea, Laurencia
Golab, Karolina
Wang, Ling-jia
Tibudan, Martin
Thomas, Celeste
Fung, John
Witkowski, Piotr
author_sort Anteby, Roi
collection PubMed
description (1) Background: The correlation between titers of islet autoantibodies (IAbs) and the loss of transplanted islets remains controversial. We sought to evaluate the prognostic utility of monitoring IAbs in diabetic patients after islet transplantation (ITx); (2) Methods: Twelve patients with Type 1 diabetes mellitus and severe hypoglycemia underwent ITx. Serum concentration of glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), and zinc transport 8 (ZnT8) autoantibodies was assessed before ITx and 0, 7, and 75 days and every 3 months post-operatively; (3) Results: IA-2A (IA-2 antibody) and ZnT8A (ZnT8 antibody) levels were not detectable before or after ITx in all patients (median follow-up of 53 months (range 24–61)). Prior to ITx, GAD antibody (GADA) was undetectable in 67% (8/12) of patients. Of those, 75% (6/8) converted to GADA+ after ITx. In 67% (4/6) of patients with GADA+ seroconversion, GADA level peaked within 3 months after ITx and subsequently declined. All patients with GADA+ seroconversion maintained long-term partial or complete islet function (insulin independence) after 1 or 2 ITx. There was no correlation between the presence of IAb-associated HLA haplotypes and the presence of IAbs before or after ITx; (4) Conclusions: There is no association between serum GADA trends and ITx outcomes. IA-2A and ZnT8A were not detectable in any of our patients before or after ITx.
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spelling pubmed-82339422021-06-27 Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus Anteby, Roi Lucander, Aaron Bachul, Piotr J. Pyda, Jordan Grybowski, Damian Basto, Lindsay Generette, Gabriela S. Perea, Laurencia Golab, Karolina Wang, Ling-jia Tibudan, Martin Thomas, Celeste Fung, John Witkowski, Piotr J Clin Med Article (1) Background: The correlation between titers of islet autoantibodies (IAbs) and the loss of transplanted islets remains controversial. We sought to evaluate the prognostic utility of monitoring IAbs in diabetic patients after islet transplantation (ITx); (2) Methods: Twelve patients with Type 1 diabetes mellitus and severe hypoglycemia underwent ITx. Serum concentration of glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), and zinc transport 8 (ZnT8) autoantibodies was assessed before ITx and 0, 7, and 75 days and every 3 months post-operatively; (3) Results: IA-2A (IA-2 antibody) and ZnT8A (ZnT8 antibody) levels were not detectable before or after ITx in all patients (median follow-up of 53 months (range 24–61)). Prior to ITx, GAD antibody (GADA) was undetectable in 67% (8/12) of patients. Of those, 75% (6/8) converted to GADA+ after ITx. In 67% (4/6) of patients with GADA+ seroconversion, GADA level peaked within 3 months after ITx and subsequently declined. All patients with GADA+ seroconversion maintained long-term partial or complete islet function (insulin independence) after 1 or 2 ITx. There was no correlation between the presence of IAb-associated HLA haplotypes and the presence of IAbs before or after ITx; (4) Conclusions: There is no association between serum GADA trends and ITx outcomes. IA-2A and ZnT8A were not detectable in any of our patients before or after ITx. MDPI 2021-06-19 /pmc/articles/PMC8233942/ /pubmed/34205321 http://dx.doi.org/10.3390/jcm10122708 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anteby, Roi
Lucander, Aaron
Bachul, Piotr J.
Pyda, Jordan
Grybowski, Damian
Basto, Lindsay
Generette, Gabriela S.
Perea, Laurencia
Golab, Karolina
Wang, Ling-jia
Tibudan, Martin
Thomas, Celeste
Fung, John
Witkowski, Piotr
Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title_full Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title_fullStr Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title_full_unstemmed Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title_short Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
title_sort evaluating the prognostic value of islet autoantibody monitoring in islet transplant recipients with long-standing type 1 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233942/
https://www.ncbi.nlm.nih.gov/pubmed/34205321
http://dx.doi.org/10.3390/jcm10122708
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