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Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this stu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234006/ https://www.ncbi.nlm.nih.gov/pubmed/34207420 http://dx.doi.org/10.3390/genes12060935 |
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author | Sun, Ruya Cui, Chunmei Zhou, Yuan Cui, Qinghua |
author_facet | Sun, Ruya Cui, Chunmei Zhou, Yuan Cui, Qinghua |
author_sort | Sun, Ruya |
collection | PubMed |
description | In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this study, we collected expression profiles across 53 human tissues and five main biofluid types. Utilizing the above dataset, we uncovered a globally positive correlation pattern between various biofluids (including blood, urine, bile, saliva and stool) and human tissues. However, significantly varied biofluid–tissue similarity levels and tendencies were observed between mRNA and lncRNA. Moreover, a higher correlation was found between biofluid types and their functionally related and anatomically closer tissues. In particular, a highly specific correlation was discovered between urine and the prostate. The biological sex of the donor was also proved to be an important influencing factor in biofluid–tissue correlation. Moreover, genes enriched in basic biological processes were found to display low variability across biofluid types, while genes enriched in catabolism-associated pathways were identified as highly variable. |
format | Online Article Text |
id | pubmed-8234006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82340062021-06-27 Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues Sun, Ruya Cui, Chunmei Zhou, Yuan Cui, Qinghua Genes (Basel) Article In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this study, we collected expression profiles across 53 human tissues and five main biofluid types. Utilizing the above dataset, we uncovered a globally positive correlation pattern between various biofluids (including blood, urine, bile, saliva and stool) and human tissues. However, significantly varied biofluid–tissue similarity levels and tendencies were observed between mRNA and lncRNA. Moreover, a higher correlation was found between biofluid types and their functionally related and anatomically closer tissues. In particular, a highly specific correlation was discovered between urine and the prostate. The biological sex of the donor was also proved to be an important influencing factor in biofluid–tissue correlation. Moreover, genes enriched in basic biological processes were found to display low variability across biofluid types, while genes enriched in catabolism-associated pathways were identified as highly variable. MDPI 2021-06-18 /pmc/articles/PMC8234006/ /pubmed/34207420 http://dx.doi.org/10.3390/genes12060935 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Ruya Cui, Chunmei Zhou, Yuan Cui, Qinghua Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title | Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title_full | Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title_fullStr | Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title_full_unstemmed | Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title_short | Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues |
title_sort | comprehensive analysis of rna expression correlations between biofluids and human tissues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234006/ https://www.ncbi.nlm.nih.gov/pubmed/34207420 http://dx.doi.org/10.3390/genes12060935 |
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