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Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues

In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this stu...

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Detalles Bibliográficos
Autores principales: Sun, Ruya, Cui, Chunmei, Zhou, Yuan, Cui, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234006/
https://www.ncbi.nlm.nih.gov/pubmed/34207420
http://dx.doi.org/10.3390/genes12060935
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author Sun, Ruya
Cui, Chunmei
Zhou, Yuan
Cui, Qinghua
author_facet Sun, Ruya
Cui, Chunmei
Zhou, Yuan
Cui, Qinghua
author_sort Sun, Ruya
collection PubMed
description In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this study, we collected expression profiles across 53 human tissues and five main biofluid types. Utilizing the above dataset, we uncovered a globally positive correlation pattern between various biofluids (including blood, urine, bile, saliva and stool) and human tissues. However, significantly varied biofluid–tissue similarity levels and tendencies were observed between mRNA and lncRNA. Moreover, a higher correlation was found between biofluid types and their functionally related and anatomically closer tissues. In particular, a highly specific correlation was discovered between urine and the prostate. The biological sex of the donor was also proved to be an important influencing factor in biofluid–tissue correlation. Moreover, genes enriched in basic biological processes were found to display low variability across biofluid types, while genes enriched in catabolism-associated pathways were identified as highly variable.
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spelling pubmed-82340062021-06-27 Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues Sun, Ruya Cui, Chunmei Zhou, Yuan Cui, Qinghua Genes (Basel) Article In recent years, biofluid has been considered a promising source of non-invasive biomarkers for health monitoring and disease diagnosis. However, the expression consistency between biofluid and human tissue, which is fundamental to RNA biomarker development, has not been fully evaluated. In this study, we collected expression profiles across 53 human tissues and five main biofluid types. Utilizing the above dataset, we uncovered a globally positive correlation pattern between various biofluids (including blood, urine, bile, saliva and stool) and human tissues. However, significantly varied biofluid–tissue similarity levels and tendencies were observed between mRNA and lncRNA. Moreover, a higher correlation was found between biofluid types and their functionally related and anatomically closer tissues. In particular, a highly specific correlation was discovered between urine and the prostate. The biological sex of the donor was also proved to be an important influencing factor in biofluid–tissue correlation. Moreover, genes enriched in basic biological processes were found to display low variability across biofluid types, while genes enriched in catabolism-associated pathways were identified as highly variable. MDPI 2021-06-18 /pmc/articles/PMC8234006/ /pubmed/34207420 http://dx.doi.org/10.3390/genes12060935 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Ruya
Cui, Chunmei
Zhou, Yuan
Cui, Qinghua
Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title_full Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title_fullStr Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title_full_unstemmed Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title_short Comprehensive Analysis of RNA Expression Correlations between Biofluids and Human Tissues
title_sort comprehensive analysis of rna expression correlations between biofluids and human tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234006/
https://www.ncbi.nlm.nih.gov/pubmed/34207420
http://dx.doi.org/10.3390/genes12060935
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