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The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart

Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic card...

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Autores principales: Dogru, Teoman, Kirik, Ali, Gurel, Hasan, Rizvi, Ali A., Rizzo, Manfredi, Sonmez, Alper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234007/
https://www.ncbi.nlm.nih.gov/pubmed/34205674
http://dx.doi.org/10.3390/ijms22126627
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author Dogru, Teoman
Kirik, Ali
Gurel, Hasan
Rizvi, Ali A.
Rizzo, Manfredi
Sonmez, Alper
author_facet Dogru, Teoman
Kirik, Ali
Gurel, Hasan
Rizvi, Ali A.
Rizzo, Manfredi
Sonmez, Alper
author_sort Dogru, Teoman
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produced by the liver and abundantly secreted into the circulation appears to play a role in insulin resistance, metabolic syndrome and inflammation. This review discusses the links between NAFLD and CVD by specifically focusing on fetuin-A’s function in the pathogenesis of NAFLD and atherosclerotic CVD.
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spelling pubmed-82340072021-06-27 The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart Dogru, Teoman Kirik, Ali Gurel, Hasan Rizvi, Ali A. Rizzo, Manfredi Sonmez, Alper Int J Mol Sci Review Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produced by the liver and abundantly secreted into the circulation appears to play a role in insulin resistance, metabolic syndrome and inflammation. This review discusses the links between NAFLD and CVD by specifically focusing on fetuin-A’s function in the pathogenesis of NAFLD and atherosclerotic CVD. MDPI 2021-06-21 /pmc/articles/PMC8234007/ /pubmed/34205674 http://dx.doi.org/10.3390/ijms22126627 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dogru, Teoman
Kirik, Ali
Gurel, Hasan
Rizvi, Ali A.
Rizzo, Manfredi
Sonmez, Alper
The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title_full The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title_fullStr The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title_full_unstemmed The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title_short The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
title_sort evolving role of fetuin-a in nonalcoholic fatty liver disease: an overview from liver to the heart
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234007/
https://www.ncbi.nlm.nih.gov/pubmed/34205674
http://dx.doi.org/10.3390/ijms22126627
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