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Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain axis. However, it is not well understood how the g...

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Detalles Bibliográficos
Autores principales: Chen, Yijing, Xu, Jinying, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234057/
https://www.ncbi.nlm.nih.gov/pubmed/34205336
http://dx.doi.org/10.3390/nu13062099
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author Chen, Yijing
Xu, Jinying
Chen, Yu
author_facet Chen, Yijing
Xu, Jinying
Chen, Yu
author_sort Chen, Yijing
collection PubMed
description Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain axis. However, it is not well understood how the gut microbiome and neurons in the brain mutually interact or how these interactions affect normal brain functioning and cognition. We summarize the mechanisms whereby the gut microbiota regulate the production, transportation, and functioning of neurotransmitters. We also discuss how microbiome dysbiosis affects cognitive function, especially in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
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spelling pubmed-82340572021-06-27 Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders Chen, Yijing Xu, Jinying Chen, Yu Nutrients Review Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain axis. However, it is not well understood how the gut microbiome and neurons in the brain mutually interact or how these interactions affect normal brain functioning and cognition. We summarize the mechanisms whereby the gut microbiota regulate the production, transportation, and functioning of neurotransmitters. We also discuss how microbiome dysbiosis affects cognitive function, especially in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. MDPI 2021-06-19 /pmc/articles/PMC8234057/ /pubmed/34205336 http://dx.doi.org/10.3390/nu13062099 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yijing
Xu, Jinying
Chen, Yu
Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title_full Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title_fullStr Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title_full_unstemmed Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title_short Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders
title_sort regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234057/
https://www.ncbi.nlm.nih.gov/pubmed/34205336
http://dx.doi.org/10.3390/nu13062099
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