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Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?

Scientific societies have provided guidelines to reduce PSA-specific harms. We studied the potential non-compliance of PSA testing with current guidelines in general practice. A cross-sectional study of a random sample of 1291 patients with a PSA test was performed between January and April 2018 in...

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Autores principales: Bernal-Soriano, Mari Carmen, Parker, Lucy Anne, López-Garrigós, Maite, Hernández-Aguado, Ildefonso, Gómez-Pérez, Luis, Caballero-Romeu, Juan-Pablo, Pastor-Valero, María, García, Nuria, Alfayate-Guerra, Rocío, Lumbreras, Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234229/
https://www.ncbi.nlm.nih.gov/pubmed/34208627
http://dx.doi.org/10.3390/jcm10122650
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author Bernal-Soriano, Mari Carmen
Parker, Lucy Anne
López-Garrigós, Maite
Hernández-Aguado, Ildefonso
Gómez-Pérez, Luis
Caballero-Romeu, Juan-Pablo
Pastor-Valero, María
García, Nuria
Alfayate-Guerra, Rocío
Lumbreras, Blanca
author_facet Bernal-Soriano, Mari Carmen
Parker, Lucy Anne
López-Garrigós, Maite
Hernández-Aguado, Ildefonso
Gómez-Pérez, Luis
Caballero-Romeu, Juan-Pablo
Pastor-Valero, María
García, Nuria
Alfayate-Guerra, Rocío
Lumbreras, Blanca
author_sort Bernal-Soriano, Mari Carmen
collection PubMed
description Scientific societies have provided guidelines to reduce PSA-specific harms. We studied the potential non-compliance of PSA testing with current guidelines in general practice. A cross-sectional study of a random sample of 1291 patients with a PSA test was performed between January and April 2018 in primary health care. Patients with a previous prostate cancer diagnosis or those who were being followed-up for previous high PSA values were excluded. Two independent researchers classified whether each test was potentially non-compliant with recommendations. We estimated frequencies of potentially non-compliant PSA determinations and calculated prevalence ratios (PR) to assess their relationship with possible explanatory variables. A total of 66% (95% CI: 62–69%) of PSA requests in asymptomatic patients were potentially non-compliant with the current guideline. This was associated with having a previous diagnosis of neoplasm (PR adjusted by age and life expectancy: 1.18; 95% CI: 1.02–1.37) as well as being a current consumer of tobacco, alcohol, or other drugs (PR: 0.80; 95% CI: 0.67–0.97). Real world data shows that patients are still frequently exposed to overdiagnosis risk with a PSA potentially non-compliant with recommendations. Patients diagnosed with another neoplasm or non-consumers of toxic substances were more exposed, probably due to increased contact with doctors or health-seeking behaviour.
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spelling pubmed-82342292021-06-27 Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines? Bernal-Soriano, Mari Carmen Parker, Lucy Anne López-Garrigós, Maite Hernández-Aguado, Ildefonso Gómez-Pérez, Luis Caballero-Romeu, Juan-Pablo Pastor-Valero, María García, Nuria Alfayate-Guerra, Rocío Lumbreras, Blanca J Clin Med Article Scientific societies have provided guidelines to reduce PSA-specific harms. We studied the potential non-compliance of PSA testing with current guidelines in general practice. A cross-sectional study of a random sample of 1291 patients with a PSA test was performed between January and April 2018 in primary health care. Patients with a previous prostate cancer diagnosis or those who were being followed-up for previous high PSA values were excluded. Two independent researchers classified whether each test was potentially non-compliant with recommendations. We estimated frequencies of potentially non-compliant PSA determinations and calculated prevalence ratios (PR) to assess their relationship with possible explanatory variables. A total of 66% (95% CI: 62–69%) of PSA requests in asymptomatic patients were potentially non-compliant with the current guideline. This was associated with having a previous diagnosis of neoplasm (PR adjusted by age and life expectancy: 1.18; 95% CI: 1.02–1.37) as well as being a current consumer of tobacco, alcohol, or other drugs (PR: 0.80; 95% CI: 0.67–0.97). Real world data shows that patients are still frequently exposed to overdiagnosis risk with a PSA potentially non-compliant with recommendations. Patients diagnosed with another neoplasm or non-consumers of toxic substances were more exposed, probably due to increased contact with doctors or health-seeking behaviour. MDPI 2021-06-16 /pmc/articles/PMC8234229/ /pubmed/34208627 http://dx.doi.org/10.3390/jcm10122650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bernal-Soriano, Mari Carmen
Parker, Lucy Anne
López-Garrigós, Maite
Hernández-Aguado, Ildefonso
Gómez-Pérez, Luis
Caballero-Romeu, Juan-Pablo
Pastor-Valero, María
García, Nuria
Alfayate-Guerra, Rocío
Lumbreras, Blanca
Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title_full Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title_fullStr Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title_full_unstemmed Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title_short Do the Prostate-Specific Antigen (PSA) Tests That Are Ordered in Clinical Practice Adhere to the Pertinent Guidelines?
title_sort do the prostate-specific antigen (psa) tests that are ordered in clinical practice adhere to the pertinent guidelines?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234229/
https://www.ncbi.nlm.nih.gov/pubmed/34208627
http://dx.doi.org/10.3390/jcm10122650
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