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SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO mutants were embryonic lethal while SOS2-KO mice were viable led to initially...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234257/ https://www.ncbi.nlm.nih.gov/pubmed/34205562 http://dx.doi.org/10.3390/ijms22126613 |