CaCO(3)–Chitosan Composites Granules for Instant Hemostasis and Wound Healing

Excessive bleeding induces a high risk of death and is a leading cause of deaths that result from traffic accidents and military conflict. In this paper, we developed a novel porous chitosan–CaCO(3) (CS–CaCO(3)) composite material and investigated its hemostatic properties and wound healing performance. The CS–CaCO(3) composites material was prepared via a wet-granulation method. Granulation increases the infiltrating ability of the CS–CaCO(3) composites material. The improved water absorption ability was enhanced to 460% for the CS–CaCO(3) composites material compared to the CaCO(3) or chitosan with only one single component. The coagulation studies in vivo illustrated that the blood clotting time was greatly reduced from 31 s for CaCO(3) to 16 s for the CS–CaCO(3) composite material. According to the results of the wound healing experiments in rats, it was found that the CS–CaCO3 composite material can promote wound healing. The CS–CaCO(3) composite material could accelerate wound healing to a rate of 9 days, compared with 12 days for the CaCO(3). The hemostatic activity, biocompatibility, and low cost of CS–CaCO(3) composite material make it a potential agent for effective hemostatic and wound healing materials.