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External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury
We propose a new set of clinical variables for a more accurate early prediction of safe decannulation in patients with severe acquired brain injury (ABI), during a post-acute rehabilitation course. Starting from the already validated DecaPreT scale, we tested the accuracy of new logistic regression...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234369/ https://www.ncbi.nlm.nih.gov/pubmed/34204352 http://dx.doi.org/10.3390/brainsci11060799 |
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author | Leto, Elio Lofaro, Danilo Lucca, Lucia Francesca Ursino, Maria Rogano, Stefania Scola, Paolo Tonin, Paolo Conforti, Domenico Cerasa, Antonio |
author_facet | Leto, Elio Lofaro, Danilo Lucca, Lucia Francesca Ursino, Maria Rogano, Stefania Scola, Paolo Tonin, Paolo Conforti, Domenico Cerasa, Antonio |
author_sort | Leto, Elio |
collection | PubMed |
description | We propose a new set of clinical variables for a more accurate early prediction of safe decannulation in patients with severe acquired brain injury (ABI), during a post-acute rehabilitation course. Starting from the already validated DecaPreT scale, we tested the accuracy of new logistic regression models where the coefficients of the original predictors were reestimated. Patients with tracheostomy were retrospectively selected from the database of the neurorehabilitation unit at the S. Anna Institute of Crotone, Italy. New potential predictors of decannulation were screened from variables collected on admission during clinical examination, including (a) age at injury, (b) coma recovery scale-revised (CRS-r) scores, and c) length of ICU period. Of 273 patients with ABI (mean age 53.01 years; 34% female; median DecaPreT = 0.61), 61.5% were safely decannulated before discharge. In the validation phase, the linear logistic prediction model, created with the new multivariable predictors, obtained an area under the receiver operating characteristics curve of 0.901. Our model improves the reliability of simple clinical variables detected at the admission of the post-acute phase in predicting decannulation of ABI patients, thus helping clinicians to plan better rehabilitation. |
format | Online Article Text |
id | pubmed-8234369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82343692021-06-27 External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury Leto, Elio Lofaro, Danilo Lucca, Lucia Francesca Ursino, Maria Rogano, Stefania Scola, Paolo Tonin, Paolo Conforti, Domenico Cerasa, Antonio Brain Sci Article We propose a new set of clinical variables for a more accurate early prediction of safe decannulation in patients with severe acquired brain injury (ABI), during a post-acute rehabilitation course. Starting from the already validated DecaPreT scale, we tested the accuracy of new logistic regression models where the coefficients of the original predictors were reestimated. Patients with tracheostomy were retrospectively selected from the database of the neurorehabilitation unit at the S. Anna Institute of Crotone, Italy. New potential predictors of decannulation were screened from variables collected on admission during clinical examination, including (a) age at injury, (b) coma recovery scale-revised (CRS-r) scores, and c) length of ICU period. Of 273 patients with ABI (mean age 53.01 years; 34% female; median DecaPreT = 0.61), 61.5% were safely decannulated before discharge. In the validation phase, the linear logistic prediction model, created with the new multivariable predictors, obtained an area under the receiver operating characteristics curve of 0.901. Our model improves the reliability of simple clinical variables detected at the admission of the post-acute phase in predicting decannulation of ABI patients, thus helping clinicians to plan better rehabilitation. MDPI 2021-06-17 /pmc/articles/PMC8234369/ /pubmed/34204352 http://dx.doi.org/10.3390/brainsci11060799 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leto, Elio Lofaro, Danilo Lucca, Lucia Francesca Ursino, Maria Rogano, Stefania Scola, Paolo Tonin, Paolo Conforti, Domenico Cerasa, Antonio External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title | External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title_full | External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title_fullStr | External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title_full_unstemmed | External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title_short | External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury |
title_sort | external validation and calibration of the decapret prediction model for decannulation in patients with acquired brain injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234369/ https://www.ncbi.nlm.nih.gov/pubmed/34204352 http://dx.doi.org/10.3390/brainsci11060799 |
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