A Radionuclide Generator of High-Purity Bi-213 for Instant Labeling

A new two-column (225)Ac/(213)Bi generator was developed specifically for using (225)Ac containing an impurity of long lived (227)Ac. The parent (225)Ac was retained on the first Actinide Resin column, while (213)Bi was accumulated on the second column filled with AG MP-50 resin via continuous elution and decay of intermediate (221)Fr. The (213)Bi accumulation was realized in circulation mode which allowed a compact generator design. It was demonstrated that (213)Bi could be quickly and effectively extracted from AG MP-50 in form of complexes with various chelating agents including DTPA and DOTA. The performance of the generator presented and a conventional single-column generator on the base of AG MP-50 was tested and both generators were loaded with (225)Ac containing (227)Ac impurity. The (213)Bi generation efficiencies were comparable and greater than 70%, whereas the developed generator provided a deeper degree of purification of (213)Bi from Ac isotopes and decay products of (227)Ac.